12 GHz CMOS MEMS Lab-on-chip System for Detection of Concentration of Suspended Particles in Bio-suspensions

Subhajit Guha, Marco Lisker, Andreas Trusch, Alexander Wolf, Chafik Meliani, Christian Wenger

Abstract

This work presents a high frequency (X-band) CMOS dielectric sensor with hybrid microfluidic integration, applied to biosensing techniques; primarily to detect concentration of suspended particles in a solution. The detection technique is based on capacitive sensing of varying permittivity of the aqueous solution caused by different concentrations of suspended particles. The sensor chip is fabricated in 0.25 µm SiGe:C BiCMOS technology of IHP with post processed PDMS microfluidic hybrid integration. The operating frequency of the sensor is 12.3 GHz and draws a DC power of approximately 35 mW from 3 V power supply. The dielectric sensitivity of the chip was characterized and calibrated using different organic fluids (alcohols); a sensitivity of 100 MHz/permittivity was measured with the sensor. After the calibration phase, the sensor was further used to measure the concentration of glucose in a homogeneous glucose solution. Frequency down-shift of 250 MHz/10% increase in water concentration in the homogeneous solution was observed. In order to analyse the concentration of suspended particles in a solution various concentrations of micro-beads in acetone solution were measured. Approximately a frequency up-shift of 125 MHz/10 µl increase in bead volume in acetone was observed. The overall chip size is 2.76 mm2.

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Paper Citation


in Harvard Style

Guha S., Lisker M., Trusch A., Wolf A., Meliani C. and Wenger C. (2015). 12 GHz CMOS MEMS Lab-on-chip System for Detection of Concentration of Suspended Particles in Bio-suspensions . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015) ISBN 978-989-758-071-0, pages 49-57. DOI: 10.5220/0005219300490057


in Bibtex Style

@conference{biodevices15,
author={Subhajit Guha and Marco Lisker and Andreas Trusch and Alexander Wolf and Chafik Meliani and Christian Wenger},
title={12 GHz CMOS MEMS Lab-on-chip System for Detection of Concentration of Suspended Particles in Bio-suspensions},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)},
year={2015},
pages={49-57},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005219300490057},
isbn={978-989-758-071-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)
TI - 12 GHz CMOS MEMS Lab-on-chip System for Detection of Concentration of Suspended Particles in Bio-suspensions
SN - 978-989-758-071-0
AU - Guha S.
AU - Lisker M.
AU - Trusch A.
AU - Wolf A.
AU - Meliani C.
AU - Wenger C.
PY - 2015
SP - 49
EP - 57
DO - 10.5220/0005219300490057