Design of an Optimized Distal Optic for Non Linear Endomicroscopy

Claire Lefort, Hussein Hamzeh, Liu Wei, David Sevrain, Philippe Leproux, Frédéric Pain, Darine Abi Haidar

Abstract

The development of a nonlinear endomicroscope is justified by the need for a non-invasive diagnosis tool to assess at the cellular level, in vivo and in live the presence of pathologies like cancer in a patient body. To do so, an important effort has to be made in the miniaturization of the distal head of the endoscope. We report in this paper our work on the characterization of a commercial gradient index (GRIN) lens, especially its possible fluorescence emission and ability to image biological structures. We show that the fluorescence of the peripheral glue of the GRIN lens does not have impact on the fluorescence images but can lead to perturbations to measure fluorescence lifetime and emission spectrum. The axial and lateral resolutions are obtained by imaging 1 μm diameter gold beads. The results show a good agreement with values from the literature. Finally, we simulate an endomicroscope combining an appropriate double-clad fibre (DCF) with the GRIN lens and a tubular piezoelectric scanner (PZT) scanning head. Variations of parameters values like fibre tilt angle and distance between the DCF and the GRIN lens allow to discuss on the performances of this device in terms of working distance (WD), magnification, field of view (FOV) and coupling efficiency.

References

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Paper Citation


in Harvard Style

Lefort C., Hamzeh H., Wei L., Sevrain D., Leproux P., Pain F. and Abi Haidar D. (2015). Design of an Optimized Distal Optic for Non Linear Endomicroscopy . In Proceedings of the 3rd International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS, ISBN 978-989-758-092-5, pages 5-12. DOI: 10.5220/0005249700050012


in Bibtex Style

@conference{photoptics15,
author={Claire Lefort and Hussein Hamzeh and Liu Wei and David Sevrain and Philippe Leproux and Frédéric Pain and Darine Abi Haidar},
title={Design of an Optimized Distal Optic for Non Linear Endomicroscopy},
booktitle={Proceedings of the 3rd International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,},
year={2015},
pages={5-12},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005249700050012},
isbn={978-989-758-092-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 3rd International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,
TI - Design of an Optimized Distal Optic for Non Linear Endomicroscopy
SN - 978-989-758-092-5
AU - Lefort C.
AU - Hamzeh H.
AU - Wei L.
AU - Sevrain D.
AU - Leproux P.
AU - Pain F.
AU - Abi Haidar D.
PY - 2015
SP - 5
EP - 12
DO - 10.5220/0005249700050012