In Silico Analysis of Interactions Between NFkB and HSF Pathways

Jaroslaw Smieja, Malgorzata Kardynska, Anna Naumowicz, Patryk Janus, Piotr Widlak, Marek Kimmel

Abstract

Motivation: Inhibition of NFkB pathway is known to promote apoptosis and therefore may constitute one of the goals in anticancer therapies. Experimental results show that heat shock induces such inhibition in cancer cells. However, the mechanisms of interactions between heat shock and NFkB pathways are not fully understood yet. Development of a combined mathematical model of these pathways and its subsequent computational analysis should help to uncover these mechanisms and determine the time window in which heat shock treatment preceding chemotherapy would be the most efficient. Results: An original mathematical model has been developed, allowing for computational testing of various hypotheses concerning main sources of interplay between HSF and NFkB pathways. Computational analysis strongly suggests that the competition for IKK, known from literature, cannot be the only mechanism. Two plausible hypotheses are that either a kinase activating IKK can misfold due to heat shock or that heat shock affects TNF receptors, blocking activation of NFkB pathway at the cell membrane.

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Paper Citation


in Harvard Style

Smieja J., Kardynska M., Naumowicz A., Janus P., Widlak P. and Kimmel M. (2015). In Silico Analysis of Interactions Between NFkB and HSF Pathways . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2015) ISBN 978-989-758-070-3, pages 201-206. DOI: 10.5220/0005256602010206


in Bibtex Style

@conference{bioinformatics15,
author={Jaroslaw Smieja and Malgorzata Kardynska and Anna Naumowicz and Patryk Janus and Piotr Widlak and Marek Kimmel},
title={In Silico Analysis of Interactions Between NFkB and HSF Pathways},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2015)},
year={2015},
pages={201-206},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005256602010206},
isbn={978-989-758-070-3},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2015)
TI - In Silico Analysis of Interactions Between NFkB and HSF Pathways
SN - 978-989-758-070-3
AU - Smieja J.
AU - Kardynska M.
AU - Naumowicz A.
AU - Janus P.
AU - Widlak P.
AU - Kimmel M.
PY - 2015
SP - 201
EP - 206
DO - 10.5220/0005256602010206