Automatic Detection of High-voltage Spindles for Parkinson’s Disease

V. Vigneron, T. Syed, Hsin Chen

Abstract

Parkinson’s disease is a progressive neurodegenerative disorder which can be characterized by several symptoms such as tremor, slowness of movements, bradykinesia/akinesia and absence of postural reflexes . . . and affects 10 million people worldwide. This paper develops a novel strategy for treating patients with PD: silence High-Voltage-Spindle that resemble the pathophysiological b-waves and contribute to the development of b-waves. Silencing HVSs is expected to delay or even prevent the development of b-waves and thus the progression of PD motor symptoms. High-voltage spindles (HVSs) are observed during waking immobility of patients. In this study, the local field potentials collected from the lesioned and control rats on multiple channels were analyzed with an online detection algorithm to identify the characteristic scillations of HVSs from the second-order statistical properties of the signals and the detection performance is investigated to obtain the optimal choices. These results provide further motivation for the real-time implementation of the automatic HVS detection systems with improved performance for pathophysiological and therapeutic applications to the thalamocortical network dysfunctions.

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Paper Citation


in Harvard Style

Vigneron V., Syed T. and Chen H. (2015). Automatic Detection of High-voltage Spindles for Parkinson’s Disease . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MPBS, (BIOSTEC 2015) ISBN 978-989-758-069-7, pages 372-378. DOI: 10.5220/0005328503720378


in Bibtex Style

@conference{mpbs15,
author={V. Vigneron and T. Syed and Hsin Chen},
title={Automatic Detection of High-voltage Spindles for Parkinson’s Disease},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MPBS, (BIOSTEC 2015)},
year={2015},
pages={372-378},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005328503720378},
isbn={978-989-758-069-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MPBS, (BIOSTEC 2015)
TI - Automatic Detection of High-voltage Spindles for Parkinson’s Disease
SN - 978-989-758-069-7
AU - Vigneron V.
AU - Syed T.
AU - Chen H.
PY - 2015
SP - 372
EP - 378
DO - 10.5220/0005328503720378