Predictors of Timed “Up-and-Go” Test in Elderly with Knee Osteoarthritis

Priscila Marconcin, Margarida Espanha, Flávia Yázigi, Júlia Teles


Knee Osteoarthritis (KOA) and aging are conditions that can compromise physical function and quality of life of human being. Thus, performance-based tests and specific self-reported measures related with KOA and general health-related quality of life (QoL) should be used in clinical intervention with elderlies. The study aim was to investigate which factors best predict the performance of the Timed “up-and-go” test in the elderly people with KOA. Eligibility criteria were age ≥ 60 years and uni or bilateral KOA. Subject performed physical tests [Timed “up-and-go” (TUG), Six Minutes Waking Test (6MWT), Five Repetition Sit-to-Stand Test (FRSTST)], Handgrip, 6 meters gait speed, Standing Balance], and filled self-reported questionnaires [Knee Injury and Osteoarthritis Outcome Score (KOOS), health-related quality of life (EQ-5D-5F) and International Physical Activity Questionnaire (IPAQ)]. Pearson and Spearman coefficients were used for correlation analysis and multiple linear regression analysis to identify the significant predictors of Timed “up-and-go”. Results: Final sample included 67 patients, 69±6 years of age. Timed “up-and-go” can be explained by two models. The best model (explained 80.7% of variance) included FRSTST, 6MWT, Gait Speed, KOOS ADL and EQ-5D-5F Self-Care variables. Conclusion: Functional strength, mobility, gait speed, and perceived limitation in activities of daily living influenced the TUG performance.


  1. Alley, D. E., Shardell, M. D., Peters, K. W., McLean, R. R., Dam, T. T., Kenny, A. M., Cawthon, P. M., (2014). Grip strength cutpoints for the identification of clinically relevant weakness. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 559-566.
  2. Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., Christy, W., Cooke, T. D., Greenwald, R., Hochberg, M., et al., (1986). Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee. Arthritis & Rheumatism, 29(8), 1039-1049.
  3. Bijlsma, J. W. J., Berenbaum, F., & Lafeber, F. P. J. G., (2011). Osteoarthritis: an update with relevance for clinical practice. The Lancet, 377(9783), 2115-2126.
  4. Bohannon, R. W., (1995). Sit-to-stand test for measuring performance of lower extremity muscles. Perceptual and Motor Skills, 80(1), 163-166.
  5. Bohannon, R. W., (2011). Test-retest reliability of the five-repetition sit-to-stand test: a systematic review of the literature involving adults. Journal of Strength and Conditioning Research, 25(11), 3205-3207.
  6. Cesari, M., Kritchevsky, S. B., Newman, A. B., Simonsick, E. M., Harris, T. B., Penninx, B. W. Pahor, M., (2009). Added Value of Physical Performance Measures in Predicting Adverse Health-Related Events: Results from the Health, Aging, and Body Composition Study. Journal of the American Geriatrics Society, 57(2), 251-259.
  7. Craig, C. L., Marshall, A. L., Sjostrom, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., Oja, P., (2003). International physical activity questionnaire: 12- country reliability and validity. Medicine & Science in Sports & Exercise, 35(8), 1381-1395.
  8. Creamer, P., Lethbridge Cejku, M., & Hochberg, M. C., (2000). Factors associated with functional impairment in symptomatic knee osteoarthritis. The Journal of Rheumatology, 39(5), 490-496.
  9. Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Zamboni, M., (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 39(4), 412- 423.
  10. Davis, M. A., Ettinger, W. H., Neuhaus, J. M., & Mallon, K. P., (1991). Knee osteoarthritis and physical functioning: evidence from the NHANES I Epidemiologic Follow-up Study. The Journal of Rheumatology, 18(4), 591-598.
  11. Dobson, F., Hinman, R. S., Roos, E. M., Abbott, J. H., Stratford, P., Davis, A. M., Bennell, K. L., (2013). OARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis. Osteoarthritis and Cartilage, 21(8), 1042-1052.
  12. Escalante, Y., García-Hermoso, A., & Saavedra, J. M., (2011). Effects of exercise on functional aerobic capacity in lower limb osteoarthritis: A systematic review. Journal of Science and Medicine in Sport, 14(3), 190-198.
  13. Ferreira, P. L., Ferreira, L. N., & Pereira, L. N., (2013). Contribution for the Validation of the Portuguese Version of EQ-5D. Acta Médica Portuguesa, 26, 6.
  14. Giampaoli, S., Ferrucci, L., Cecchi, F., Lo Noce, C., Poce, A., Dima, F., Menotti, A., (1999). Hand-grip strength predicts incident disability in non-disabled older men. Age Ageing, 28(3), 283-288.
  15. Goncalves, R. S., Cabri, J., Pinheiro, J. P., & Ferreira, P. L., (2009). Cross-cultural adaptation and validation of the Portuguese version of the Knee injury and Osteoarthritis Outcome Score (KOOS). Osteoarthritis and Cartilage, 17(9), 1156-1162.
  16. Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Wallace, R. B., (1994). A short physical performance battery assessing lower extremity function: association with selfreported disability and prediction of mortality and nursing home admission. The Journals of Gerontology, 49(2), M85-94.
  17. Hoeymans, N., Feskens, E. J. M., van den Bos, G. A. M., & Kromhout, D., (1996). Measuring functional status: Cross-sectional and longitudinal associations between performance and self-report (Zutphen Elderly Study 1990-1993). Journal of Clinical Epidemiology, 49(10), 1103-1110.
  18. Johnson, V. L., & Hunter, D. J., (2014). The epidemiology of osteoarthritis. Best Practice & Research Clinical Rheumatology, 28(1), 5-15.
  19. Juhakoski, R., Tenhonen, S., Anttonen, T., Kauppinen, T., & Arokoski, J. P., (2008). Factors affecting selfreported pain and physical function in patients with hip osteoarthritis. Archives of Physical Medicine and Rehabilitation, 89(6), 1066-1073.
  20. Lamb, S., Guralnik, J., Buchner, D., Ferrucci, L., Hochberg, M., Simonsick, E., & Fried, L., (2000). Factors that modify the association between knee pain and mobility limitation in older women: the Women's Health and Aging Study. Annals of the Rheumatic Diseases, 59(5), 331-337.
  21. Lee, P., Macfarlane, D., Lam, T., & Stewart, S., (2011). Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review. International Journal of Behavioural Nutrition and Physical Activity, 8(1), 115.
  22. Lord, S. R., & Menz, H. B., (2002). Physiologic, and health predictors of 6-minute walk performance in older people. Archives of Physical Medicine and Rehabilitation, 83(7), 907-911.
  23. Lord, S. R., Murray, S. M., Chapman, K., Munro, B., & Tiedemann, A., (2002). Sit-to-Stand Performance Depends on Sensation, Speed, Balance, and Psychological Status in Addition to Strength in Older People. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57(8), M539-M543.
  24. Machado, G. P., Gignac, M. A., & Badley, E. M., (2008). Participation restrictions among older adults with osteoarthritis: a mediated model of physical symptoms, activity limitations, and depression. Arthritis & Rheumatology, 59(1), 129-135.
  25. Mansournia, M. A., Danaei, G., Forouzanfar, M. H., Mahmoodi, M., Jamali, M., Mansournia, N., & Mohammad, K., (2012). Effect of physical activity on functional performance and knee pain in patients with osteoarthritis: analysis with marginal structural models. Epidemiology, 23(4), 631-640.
  26. Martinez, B. P., Gomes, I. B., Oliveira, C. S., Ramos, I. R., Rocha, M. D., Forgiarini Junior, L. A., Camelier, F.W., & Camelier, A. A., (2015). Accuracy of the Timed Up and Go test for predicting sarcopenia in elderly hospitalized patients. Clinics, 70(5), 369-372.
  27. Pickard, A. S., Kohlmann, T., Janssen, M. F., Bonsel, G., Rosenbloom, S., & Cella, D., (2007). Evaluating Equivalency Between Response Systems: Application of the Rasch Model to a 3-Level and 5-Level EQ-5D. Medical Care, 45(9), 812-819.
  28. Podsiadlo, D., & Richardson, S., (1991). The timed "Up & Go": a test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39(2), 142-148.
  29. Reid, K. F., & Fielding, R. A., (2012). Skeletal muscle power: a critical determinant of physical functioning in older adults. Exercise and Sport Sciences Reviews, 40(1), 4-12.
  30. Rikli, R. E., & Jones, C. J., (1998). The reliability and validity of a 6-minute walk test as a measure of physical endurance in older adults. Journal of Aging and Physical Activity, 6, 363-375.
  31. Roos, E. M., & Lohmander, L. S., (2003). The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health and Quality of Life Outcomes, 1, 64-64.
  32. Rose, D. J., (2003). A Comprehensive Balance and Mobility Training Program. Champaign: Human Kinectics.
  33. Rutten, A., & Abu-Omar, K., (2004). Prevalence of physical activity in the European Union. Soz Praventivmed, 49(4), 281-289.
  34. Sabirli, F., Paker, N., & Bugdayci, D., (2013). The relationship between Knee Injury and Osteoarthritis Outcome Score (KOOS) and Timed Up and Go test in patients with symptomatic knee osteoarthritis. Rheumatology International, 33(10), 2691-2694.
  35. Schlenk, E. A., Lias, J. L., Sereika, S. M., Dunbar-Jacob, J., & Kwoh, C. K., (2011). Improving Physical Activity and Function in Overweight and Obese Older Adults with Osteoarthritis of the Knee: A Feasibility Study. Rehabilitation Nursing, 36(1), 32-42.
  36. Sheskin, D. J., (2007). Handbook of Parametric and Nonparametric Statistical Procedures Boca Raton, Florida: Chapman and Hall/CRC.
  37. Shumway-Cook, A., Brauer, S., & Woollacott, M., (2000). Predicting the probability for falls in communitydwelling older adults using the Timed up & go Test. Physical Therapy, 80(9), 896-903.
  38. Stratford, P. W., & Kennedy, D. M., (2006). Performance measures were necessary to obtain a complete picture of osteoarthritic patients. The Journal of Clinical Epidemiology, 59(2), 160-167.
  39. Tanimura C1, Morimoto M., Hiramatsu K., Hagino H., (2011). Difficulties in the daily life of patients with osteoarthritis of the knee: scale development and descriptive study. Journal of Clinical Nursing, 20(5- 6), 743-53.
  40. Terwee, C. B., van der Slikke, R. M., van Lummel, R. C., Benink, R. J., Meijers, W. G., & de Vet, H. C., (2006). Self-reported physical functioning was more influenced by pain than performance-based physical functioning in knee-osteoarthritis patients. The Journal of Clinical Epidemiology, 59(7), 724-731.
  41. van Dijk, G. M., Veenhof, C., Spreeuwenberg, P., Coene, N., Burger, B. J., van Schaardenburg, D.,& Dekker, J., (2010). Prognosis of limitations in activities in osteoarthritis of the hip or knee: a 3-year cohort study. Archives of Physical Medicine and Rehabilitation, 91(1), 58-66.
  42. Wilhelm, E. N., Rech, A., Minozzo, F., Radaelli, R., Botton, C. E., & Pinto, R. S., (2014). Relationship between quadriceps femoris echo intensity, muscle power, and functional capacity of older men. Age (Dordr), 36(3), 9625.
  43. Wood, L., Peat, G., Thomas, E., Hay, E. M., & Sim, J., (2008). Associations between physical examination and self-reported physical function in older community-dwelling adults with knee pain. Physical Therapy, 88(1), 33-42.

Paper Citation

in Harvard Style

Marconcin P., Espanha M., Yázigi F. and Teles J. (2015). Predictors of Timed “Up-and-Go” Test in Elderly with Knee Osteoarthritis . In Proceedings of the 3rd International Congress on Sport Sciences Research and Technology Support - Volume 1: icSPORTS, ISBN 978-989-758-159-5, pages 97-103. DOI: 10.5220/0005611300970103

in Bibtex Style

author={Priscila Marconcin and Margarida Espanha and Flávia Yázigi and Júlia Teles},
title={Predictors of Timed “Up-and-Go” Test in Elderly with Knee Osteoarthritis},
booktitle={Proceedings of the 3rd International Congress on Sport Sciences Research and Technology Support - Volume 1: icSPORTS,},

in EndNote Style

JO - Proceedings of the 3rd International Congress on Sport Sciences Research and Technology Support - Volume 1: icSPORTS,
TI - Predictors of Timed “Up-and-Go” Test in Elderly with Knee Osteoarthritis
SN - 978-989-758-159-5
AU - Marconcin P.
AU - Espanha M.
AU - Yázigi F.
AU - Teles J.
PY - 2015
SP - 97
EP - 103
DO - 10.5220/0005611300970103