Splice Site Prediction: Transferring Knowledge Across Organisms
Simos Kazantzidis, Anastasia Krithara, George Paliouras
2017
Abstract
As more genomes are sequenced, there is an increasing need for automated gene prediction. One of the subproblems of the gene prediction, is the splice sites recognition. In eukaryotic genes, splice sites mark the boundaries between exons and introns. Even though, there are organisms which are well studied and their splice sites are known, there are plenty others which have not been studied well enough. In this work, we propose two transfer learning approaches for the splice site recognition problem, which take into account the knowledge we have from the well-studied organisms. We use different representations for the sequences such as the n-gram graph representation and a representation based on biological motifs. Furthermore, we study the case where more than one organisms are available for training and we incorporate information from the phylogenetic analysis between organisms. An extensive evaluation has taken place. The results indicate that the proposed representations and approaches are very promising.
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in Harvard Style
Kazantzidis S., Krithara A. and Paliouras G. (2017). Splice Site Prediction: Transferring Knowledge Across Organisms. In - BIOINFORMATICS, (BIOSTEC 2017) ISBN , pages 0-0. DOI: 10.5220/0006164400001488
in Bibtex Style
@conference{bioinformatics17,
author={Simos Kazantzidis and Anastasia Krithara and George Paliouras},
title={Splice Site Prediction: Transferring Knowledge Across Organisms},
booktitle={ - BIOINFORMATICS, (BIOSTEC 2017)},
year={2017},
pages={},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006164400001488},
isbn={},
}
in EndNote Style
TY - CONF
JO - - BIOINFORMATICS, (BIOSTEC 2017)
TI - Splice Site Prediction: Transferring Knowledge Across Organisms
SN -
AU - Kazantzidis S.
AU - Krithara A.
AU - Paliouras G.
PY - 2017
SP - 0
EP - 0
DO - 10.5220/0006164400001488