A Qualitative Framework Dedicated to Toxicology

Benjamin Miraglio, Gilles Bernot, Jean-Paul Comet, Christine Risso-de Faverney

2017

Abstract

Emerging constraints have led the toxicology community to complete the classical paradigm of toxicology with the study of molecular events underlying the toxicity of a chemical substance. This evolution motivates the emergence of new modelling approaches for toxicology. In this article, we introduce a qualitative rulebased formalism dedicated to the domain of toxicology. This new formalism departs from other rule-based formalisms such as BioChAM because it directly encodes possible alterations of equilibrium, instead of making equilibriums emerge from the dynamics of the model. Using a simple example of the energy metabolism, we show that this formalism is able to describe both the normal evolution of a biological system and its possible toxic disruptions.

Paper Citation

in Harvard Style

Miraglio B., Bernot G., Comet J. and Risso-de Faverney C. (2017). A Qualitative Framework Dedicated to Toxicology. In - BIOINFORMATICS, (BIOSTEC 2017) ISBN , pages 0-0. DOI: 10.5220/0006168200001488

in Bibtex Style

@conference{bioinformatics17,
author={Benjamin Miraglio and Gilles Bernot and Jean-Paul Comet and Christine Risso-de Faverney},
title={A Qualitative Framework Dedicated to Toxicology},
booktitle={ - BIOINFORMATICS, (BIOSTEC 2017)},
year={2017},
pages={},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006168200001488},
isbn={},
}

in EndNote Style

TY - CONF

JO - - BIOINFORMATICS, (BIOSTEC 2017)
TI - A Qualitative Framework Dedicated to Toxicology
SN -
AU - Miraglio B.
AU - Bernot G.
AU - Comet J.
AU - Risso-de Faverney C.
PY - 2017
SP - 0
EP - 0
DO - 10.5220/0006168200001488