The Role of Vanilloid and Cannabinoid Receptors in Taste and Pain Perception in Burning Mouth Syndrome

Jenny Sunariani, I Komang Evan Wijaksana, Ernie Maduratna Setiawatie

Abstract

Burning mouth syndrome (BMS) refers to chronic and idiopathic pain in the oral cavity. Common clinical symptoms include taste perception disturbance and persistent dysgeusia, which present along with chronic pain. This article aims to review the role of vanilloid and cannabinoid receptors in taste perception and pain in BMS patients. The peripheral gustatory system not only comprise taste buds, but also the peripheral nerves innervating them. In patients with BMS, any changes in the system may affect the perception of taste and cause pain. Increasing number and distribution of vanilloid receptor TRPV-1 and cannabinoid receptor CB2, accompanied by decreasing cannabinoid receptor CB1, contribute to pain and taste perception changes. TRPV-1 is specifically sensitized by capcaisin or spiciness. Capcaisin stimulates trigeminal nerves to release prostaglandin which trigger free nerve endings to capture spicy taste perceived as pain. Increasing distribution of cannabinoid CB2 receptors on papilla foliate may cause threshold elevation of sucrose and a sour taste. In conclusion, changing both the number and distribution of vanilloid receptor TRPV-1 and cannabinoid receptor CB1 and CB2 in BMS may trigger abnormal activation of these receptors, resulting in pain and threshold change of sour taste, sweet taste and bitter taste.

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Paper Citation


in Harvard Style

Sunariani J., Wijaksana I. and Setiawatie E. (2017). The Role of Vanilloid and Cannabinoid Receptors in Taste and Pain Perception in Burning Mouth Syndrome.In Proceedings of the 7th International Meeting and the 4th Joint Scientific Meeting in Dentistry - Volume 1: TIMNAS7-JSMID4, ISBN 978-989-758-341-4, pages 99-102. DOI: 10.5220/0007292900990102


in Bibtex Style

@conference{timnas7-jsmid417,
author={Jenny Sunariani and I Komang Evan Wijaksana and Ernie Maduratna Setiawatie},
title={The Role of Vanilloid and Cannabinoid Receptors in Taste and Pain Perception in Burning Mouth Syndrome},
booktitle={Proceedings of the 7th International Meeting and the 4th Joint Scientific Meeting in Dentistry - Volume 1: TIMNAS7-JSMID4,},
year={2017},
pages={99-102},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007292900990102},
isbn={978-989-758-341-4},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 7th International Meeting and the 4th Joint Scientific Meeting in Dentistry - Volume 1: TIMNAS7-JSMID4,
TI - The Role of Vanilloid and Cannabinoid Receptors in Taste and Pain Perception in Burning Mouth Syndrome
SN - 978-989-758-341-4
AU - Sunariani J.
AU - Wijaksana I.
AU - Setiawatie E.
PY - 2017
SP - 99
EP - 102
DO - 10.5220/0007292900990102