Role of Nonstructural-1 Protein (NS1) Dengue Virus in Dengue Hemorrhagic Fever Pathogenesis

Musofa Rusli

Abstract

Dengue virus infection is a rapidly spreading arboviral disease and is an important cause of morbidity and mortality in most tropical and subtropical regions. There is currently no cure or vaccine for this infection, and the efforts for vector control and clinical management have not been successful and effective in reducing vector populations and case fatality rates. NS1 has an essential role for dengue virus viability and does not have clear biological activity, but seems to have particular immunological activities. NS1 proteins and anti-NS1 antibodies have a role associated with the autoimmune response mechanism that occur in the pathogenesis of dengue virus infection. Anti-NS1 antibodies show cross-reaction activity against platelets and human endothelial cells and cause a risk of hemorrhage and plasma leakage. Recent use of NS1 includes a simple bedside rapid diagnostic tool and vaccine candidate

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Paper Citation


in Harvard Style

Rusli M. (2017). Role of Nonstructural-1 Protein (NS1) Dengue Virus in Dengue Hemorrhagic Fever Pathogenesis.In Proceedings of the International Meeting on Regenerative Medicine - Volume 1: IMRM, ISBN 978-989-758-334-6, pages 454-460. DOI: 10.5220/0007323004540460


in Bibtex Style

@conference{imrm17,
author={Musofa Rusli},
title={Role of Nonstructural-1 Protein (NS1) Dengue Virus in Dengue Hemorrhagic Fever Pathogenesis},
booktitle={Proceedings of the International Meeting on Regenerative Medicine - Volume 1: IMRM,},
year={2017},
pages={454-460},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007323004540460},
isbn={978-989-758-334-6},
}


in EndNote Style

TY - CONF

JO - Proceedings of the International Meeting on Regenerative Medicine - Volume 1: IMRM,
TI - Role of Nonstructural-1 Protein (NS1) Dengue Virus in Dengue Hemorrhagic Fever Pathogenesis
SN - 978-989-758-334-6
AU - Rusli M.
PY - 2017
SP - 454
EP - 460
DO - 10.5220/0007323004540460