The Effect of Cantaloupe Extract on Sperm Quality of Adult White Rats (Rattus Novergicus) Strain Induced by Ciproteron Acetat

Elyna Mahruzza Putri, Achadiyani, Sunarjati, Sudigdoadi, Oki Suwarsa, Adi Santosa Maliki

Abstract

Abstract: Cyproterone acetate (CPA) induces over production of reactive oxygen species which in turn will induces male infertility. CPA directly suppress gonadotrophin releasing hormone (GnRH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). The over production of ROS causes oxidative stress on sperm mitochondria membrane, disruption of steroidogenesis in Leydig's cell due to low testosterone levels, disruption of spermatogenesis, and apoptosis of terminal cell. Cantaloupe extract (CE) contains superoxide dismutase (SOD) which can bind free radicals. Recent studies proved its potential increasing sperm cells quality. This experimental study was conducted on 28 adult Wistar rats that meet the inclusion criterias. The mice were divided into 4 groups at random, control group (P0) which given only 0.5 ml water, group 2 (P1) was given CE at a dose of 300 mg / kg / day diluted in 0.5 ml water for 60 days, group 3 (P2) was given CPA with a dose of 3mg / 100g diluted in 0.5 ml water for 60 days, group 4 (P3) was given CPA with a dose of 3mg / 100g and CE with dose 300 mg / kg / day diluted in 0.5 ml water for 60 days. The study supports the view that cantaloupe extract increases sperm quality significantly compared with the control group (p <0.05) but fails to increase sperm quality significantly in the group that had been given CPA prior to cantaloupe extract (p<0.05). Further study is required to better understand the interaction between CPA and cantaloupe extract.

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in Harvard Style

Mahruzza Putri E., Achadiyani., Sunarjati., Sudigdoadi., Suwarsa O. and Santosa Maliki A. (2017). The Effect of Cantaloupe Extract on Sperm Quality of Adult White Rats (Rattus Novergicus) Strain Induced by Ciproteron Acetat.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 80-83. DOI: 10.5220/0007333200800083


in Bibtex Style

@conference{sips17,
author={Elyna Mahruzza Putri and Achadiyani and Sunarjati and Sudigdoadi and Oki Suwarsa and Adi Santosa Maliki},
title={The Effect of Cantaloupe Extract on Sperm Quality of Adult White Rats (Rattus Novergicus) Strain Induced by Ciproteron Acetat},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={80-83},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007333200800083},
isbn={978-989-758-340-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - The Effect of Cantaloupe Extract on Sperm Quality of Adult White Rats (Rattus Novergicus) Strain Induced by Ciproteron Acetat
SN - 978-989-758-340-7
AU - Mahruzza Putri E.
AU - Achadiyani.
AU - Sunarjati.
AU - Sudigdoadi.
AU - Suwarsa O.
AU - Santosa Maliki A.
PY - 2017
SP - 80
EP - 83
DO - 10.5220/0007333200800083