Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia

Gwenny Ichsan Prabowo, Margarita Maria Maramis, Erikavitri Yulianti, Afrina Zulaikah, Zain Budi Syulthoni, Citrawati Dyah Kencono Wungu, Hendy Muagiri Margono, Retno Handajani

Abstract

Abstract: Schizophrenia is a complex and severe mental disorder which influences 0.5-1% of the global population. It is highly heritable and considered as a major health problem worldwide, including in Indonesia. The COMT Val158Met polymorphism is allegedly related to the schizophrenia predisposition. However, previous studies related to the COMT Val158Metpolymorphism among schizophrenic patients in different geographical areas have given different results. This research used cross-sectional study design. It applied a descriptive observational method which was aimed to detect the Val158Met COMT gene polymorphism in chronic schizophrenic patients. This study was conducted at the Psychiatric Unit of Dr. Soetomo Hospital Surabaya. The examination on COMT Val158Met polymorphism was conducted by PCR and followed by sequencing. The number of male chronic schizophrenic patients was higher than female (56.7 % over 43.3%) and the average age of male schizophrenic patients (38.53 ± 10.32 years old) was higher than female (41.08 ± 7.44 years old). Moreover, the number of schizophrenic patients with family history of schizophrenia reached 53.3%, which was higher than those without it, 46.7%. The PANNS total score of male schizophrenic patients reached 40.71 ± 16.07, which was higher than female, 40.31 ± 11.42. Furthermore, the sequencing analysis showed that the frequency of COMT Val158Metpolymorphism was 6.7% (2/30), the heterozygote allele was recorded at 21946 for 40% (12/30), and nucleotide substitution variant of T into A at 21971 was recorded at 3.3% (1/30) among chronic schizophrenic patients in the Psychiatric Unit of Dr. Soetomo Hospital Surabaya. There were quite large numbers of the COMTVal158Met polymorphism (6.7%), heterozygote allele at 21946 (40%), and nucleotide variant of T substitution into A at 21971 (3.3%) in chronic schizophrenic patients at the Psychiatric Unit of Dr. Soetomo Hospital Surabaya

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in Harvard Style

Ichsan Prabowo G., Maria Maramis M., Yulianti E., Zulaikah A., Budi Syulthoni Z., Dyah Kencono Wungu C., Muagiri Margono H. and Handajani R. (2017). Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 117-122. DOI: 10.5220/0007333901170122


in Bibtex Style

@conference{sips17,
author={Gwenny Ichsan Prabowo and Margarita Maria Maramis and Erikavitri Yulianti and Afrina Zulaikah and Zain Budi Syulthoni and Citrawati Dyah Kencono Wungu and Hendy Muagiri Margono and Retno Handajani},
title={Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={117-122},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007333901170122},
isbn={978-989-758-340-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia
SN - 978-989-758-340-7
AU - Ichsan Prabowo G.
AU - Maria Maramis M.
AU - Yulianti E.
AU - Zulaikah A.
AU - Budi Syulthoni Z.
AU - Dyah Kencono Wungu C.
AU - Muagiri Margono H.
AU - Handajani R.
PY - 2017
SP - 117
EP - 122
DO - 10.5220/0007333901170122