The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat

Irfan Idris, Aryadi Arsyad, A. Wardihan Sinrang, Syarifuddin Alwi

Abstract

Abstract: ET-1 and its receptors (ETA & ETB) play a pivotal role in many diseases following obesity. The dynamic relation between ET-1 and its receptor in obesity is still rarely studied. The aim of this study is to know the profile of ET-1 and its receptors in young and adult obese wistar rat. Two groups of wistar rat (young and adult rat) involved in study with obese rat and normal weight rat as a control group respectively. ET-1 plasma, ETA receptor and ETB receptor of heart and kidney was determined by ELISA. The data showed that ET-1 plasma higher (p<0.05) in adult compare to young rat in obese and control group, ETA of heart and kidney of adult rat lower (p>0.05) than young rat in obese and control group, ETB of heart of adult rat lower (p<0.05) than young rat in obese and control group, and ETB of kidney higher (p>0,05) in adult rat than young rat in control group. The ET-1 plasma level tends to increase in adult rat compare to young rat in both group, while the expression of ETA and ETB receptor are different in both group

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in Harvard Style

Idris I., Arsyad A., Wardihan Sinrang A. and Alwi S. (2017). The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 147-150. DOI: 10.5220/0007334501470150


in Bibtex Style

@conference{sips17,
author={Irfan Idris and Aryadi Arsyad and A. Wardihan Sinrang and Syarifuddin Alwi},
title={The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={147-150},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007334501470150},
isbn={978-989-758-340-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat
SN - 978-989-758-340-7
AU - Idris I.
AU - Arsyad A.
AU - Wardihan Sinrang A.
AU - Alwi S.
PY - 2017
SP - 147
EP - 150
DO - 10.5220/0007334501470150