The Miracle of Stichopus Hermanii

Noengki Prameswari

Abstract

Abstract: Introduction :Stichopushermanii, commonly known as sea cucumber or teripangemas or gamat, is one of marine biota that have been exploited for human food source and developed as pharmaceutical use. It is natural and contain various active ingredients such as hyaluronic acid, chondroitin sulphate,cell growth factor, EPA DHA, flavonoid that might have role in mechanical stress. Objective : The aim of this study is to explore the mechanism of Stichopushermanii in cell survival in mechanical stress, as antiinflammation agent, extracellular matrix remodeling and bone remodeling. Methodology :Quantitativeand qualitative test for active ingredients of Stichopushermanii was examined. Research in caviacobaya with three groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which were applied elastic separator for orthodontic tooth movement, and P1 groups, were applied for orthodontic tooth movement and Stichopushermanii 3,5 %. After treatment the caviacobaya were sacrificed. HSP 70, IL-17, collagen, integrin α2β1, alkaline phosphatase and TRAP-6 were examined with immunohistochemistry.ResultGlycine, collagen, and flavonoid are the highest result from quantitatives analysis of Stichopushermanii.Stichopushermanii can decrease HSP-70, IL-17a, Collagen type 1, and increase Integrin α2β1, TRAP6 osteoclast expression in pressure area under mechanical stress to orthodontic tooth movement. Conclusion : There are influence of active ingredient Stichopushermanii to cell survival in mechanical stress, as antiinflammation agent, extracellular matrix remodeling and bone remodeling with physiologic mechanism.

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Paper Citation


in Harvard Style

Prameswari N. (2017). The Miracle of Stichopus Hermanii.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 212-219. DOI: 10.5220/0007336102120219


in Bibtex Style

@conference{sips17,
author={Noengki Prameswari},
title={The Miracle of Stichopus Hermanii},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={212-219},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007336102120219},
isbn={978-989-758-340-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - The Miracle of Stichopus Hermanii
SN - 978-989-758-340-7
AU - Prameswari N.
PY - 2017
SP - 212
EP - 219
DO - 10.5220/0007336102120219