Synthesis and Characterization of Carboxymethyl Cellulose using Solvents Variations

Sri Yuliasmi, Henny Sri Wahyuni, Hanifah Siti Aisyah, Devi Riati

2018

Abstract

Carboxymethyl cellulose (CMC) is a cellulose derivative which is widely used in pharmaceutical and nonpharmaceutical industries. One of the important parameters in CMC synthesis is the variation of solvent medium. Solvents can affect the quality of CMC. The present study was conducted to synthesize and characterize of CMC with the best organic solvent mixture. CMC was obtained from microcrystalline cellulose by three stages, including alkalization between cellulose and sodium hydroxide with solvent; carboxymethylation using sodium monochloroacetate; neutralization and purification using glacial acetic acid-methanol. The solvent medium used were isopropanol-n butanol; benzene-ethanol-air; isopropanolbenzene; isopropanol-ethanol-air, and isopropanol-isobutanol by each variety of comparisons. CMC was characterized by Infrared Spectrophotometry. Degree of substitution and organoleptic test were then determined. The optimum condition of CMC synthesis which provided highest degree of substitution of 0.9 was found on isopropanol-ethanol solvents in ratio of 50:50. Organoleptic test showed that CMC powdered was colourless, rough, odorless and tasteless. Infrared analysis revealed the presence of carboxyl and ether functional groups in the 1600-1000 cm-1 region. It can be concluded that CMC has been succesfully synthesized using isopropanol-ethanol as the best solvent.

Paper Citation

in Harvard Style

Yuliasmi S., Wahyuni H., Aisyah H. and Riati D. (2018). Synthesis and Characterization of Carboxymethyl Cellulose using Solvents Variations.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 1015-1020. DOI: 10.5220/0010093410151020

in Bibtex Style

@conference{icosteerr18,
author={Sri Yuliasmi and Henny Sri Wahyuni and Hanifah Siti Aisyah and Devi Riati},
title={Synthesis and Characterization of Carboxymethyl Cellulose using Solvents Variations},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={1015-1020},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010093410151020},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Synthesis and Characterization of Carboxymethyl Cellulose using Solvents Variations
SN - 978-989-758-449-7
AU - Yuliasmi S.
AU - Wahyuni H.
AU - Aisyah H.
AU - Riati D.
PY - 2018
SP - 1015
EP - 1020
DO - 10.5220/0010093410151020