Expression of Caspase-3 in the Liver and Spleen Rattus norvegicus Which Infects Bacteria Klebsiella pneumonia and Klebsiella pneumoniae Extended Spectrum Beta Lactamase

I Gede Andika Sukarya, Willy Sandhika, Agung Dwi Wahyu Widodo

Abstract

Klebsiella pneumoniae (K. pneumoniae) is found in nosocomial infections and Gram-negative number two is the most dangerous. The bacteria K. pneumoniae causes unusual nosocomial infections in hospital settings. Drug resistance in bacteria K. pneumoniae ESBL production may increase the risk of death at the time of treatment. Caspase-3 is the hallmark of apoptosis. It can be used as an indicator of virulence of the infection of K. pneumoniae. This research aims to look at the effects of infection of K. pneumoniae and K. pneumoniae ESBL against eksprsi caspase-3 in the liver and spleen of rats Rattus novergicus. The study uses 12 healthy rats that were divided into three groups, namely the control group, infection K. pneumoniae, and infection K. pneumoniae ESBL. Each group of samples taken from the liver and spleen organs after 24 hours of the infection process and immunohistochemical expression to see caspase-3. Of the research results obtained, the percentage of caspase-3 expression in the liver and spleen organs in rats that infect bacteria K. pneumoniae, are higher than K. penumoniae ESBL.  The expression of caspase-3 in the liver and spleen organs is steeper than the infection of K. pneumoniae.  We conclude that the bacteria K. pneumoniae is more virulent than K. pneumoniae ESBL.

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Paper Citation


in Harvard Style

Andika Sukarya I., Sandhika W. and Wahyu Widodo A. (2018). Expression of Caspase-3 in the Liver and Spleen Rattus norvegicus Which Infects Bacteria Klebsiella pneumonia and Klebsiella pneumoniae Extended Spectrum Beta Lactamase.In Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS, ISBN 978-989-758-348-3, pages 244-248. DOI: 10.5220/0007540702440248


in Bibtex Style

@conference{icps18,
author={I Gede Andika Sukarya and Willy Sandhika and Agung Dwi Wahyu Widodo},
title={Expression of Caspase-3 in the Liver and Spleen Rattus norvegicus Which Infects Bacteria Klebsiella pneumonia and Klebsiella pneumoniae Extended Spectrum Beta Lactamase},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,},
year={2018},
pages={244-248},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007540702440248},
isbn={978-989-758-348-3},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,
TI - Expression of Caspase-3 in the Liver and Spleen Rattus norvegicus Which Infects Bacteria Klebsiella pneumonia and Klebsiella pneumoniae Extended Spectrum Beta Lactamase
SN - 978-989-758-348-3
AU - Andika Sukarya I.
AU - Sandhika W.
AU - Wahyu Widodo A.
PY - 2018
SP - 244
EP - 248
DO - 10.5220/0007540702440248