Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia

Khairunnisa Abd Rauf, Erry Gumilar Dachlan, Ariyanto Harsono

2018

Abstract

A successful spiral artery remodelling ensures adequate uteroplacental perfusion and sufficient nutrient supply to fetus. HLA-C interaction with maternal KIR determines the outcome of spiral artery remodelling. Strong KIR2DL1 inhibitory lowers cytokine expression and angiogenic factors that affect uteroplacental perfusion and nutrient supply. We analysed the decidual expression of KIR2DL1 in early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE) groups. We found a significant difference between KIR2DL1 expression and EO-PE and LO-PE groups (p <0.001), with a strong negative correlation between decidual expression of KIR2DL1 and EO-PE (p <0.001, r=-0.723), birth weight (p <0.001, r=-0,.70) and placental weight (p <0.001, r=-0.770).

Paper Citation

in Harvard Style

Rauf K., Dachlan E. and Harsono A. (2018). Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia.In Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS, ISBN 978-989-758-348-3, pages 321-324. DOI: 10.5220/0007542103210324

in Bibtex Style

@conference{icps18,
author={Khairunnisa Abd Rauf and Erry Gumilar Dachlan and Ariyanto Harsono},
title={Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,},
year={2018},
pages={321-324},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007542103210324},
isbn={978-989-758-348-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,
TI - Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia
SN - 978-989-758-348-3
AU - Rauf K.
AU - Dachlan E.
AU - Harsono A.
PY - 2018
SP - 321
EP - 324
DO - 10.5220/0007542103210324