Microsphere Fabrication of Polycaprolactone via Electrospray: Effect of Different Parameters

Dandan Wang, Yu Han, Jie Sun, Dejian Huang

Abstract

In controlled drug release systems, biodegradable and biocompatible polymer microspheres are good candidates as drug carrier due to their large surface area. Here, we used the electrospraying technique to fabricate polycaprolactone microspheres. By exploring the process parameters systematically, microspheres with different morphology were produced. The increase of feed rate increased the particle size and collapse of the particle, a feed rate of 0.2 μL/min was found to produce narrow size distributed microspheres with the average size of ~4 μm. Our study shows that electrospray is a promising technique to fabricate microspheres applied in controlled drug delivery systems.

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Paper Citation


in Harvard Style

Wang D., Han Y., Sun J. and Huang D. (2018). Microsphere Fabrication of Polycaprolactone via Electrospray: Effect of Different Parameters.In The Second International Conference on Materials Chemistry and Environmental Protection - MEEP, ISBN 978-989-758-360-5, pages 5-9. DOI: 10.5220/0008184500050009


in Bibtex Style

@conference{meep18,
author={Dandan Wang and Yu Han and Jie Sun and Dejian Huang},
title={Microsphere Fabrication of Polycaprolactone via Electrospray: Effect of Different Parameters},
booktitle={The Second International Conference on Materials Chemistry and Environmental Protection - MEEP,},
year={2018},
pages={5-9},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008184500050009},
isbn={978-989-758-360-5},
}


in EndNote Style

TY - CONF

JO - The Second International Conference on Materials Chemistry and Environmental Protection - MEEP,
TI - Microsphere Fabrication of Polycaprolactone via Electrospray: Effect of Different Parameters
SN - 978-989-758-360-5
AU - Wang D.
AU - Han Y.
AU - Sun J.
AU - Huang D.
PY - 2018
SP - 5
EP - 9
DO - 10.5220/0008184500050009