Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device

A. Moita, C. Caldeira, F. Jacinto, R. Lima, E. Vega, A. Moreira

Abstract

The present paper addresses the final tests (concerning the transport section) of a microfluidic device to be used in cancer diagnostics, based on the mechanical properties of the cells and particularly on deformability. Following the previous work, which established the materials to be used, according to the wetting properties and their influence on the dynamic response of the droplets (which are electrostatically actuated) this paper presents the final simulations to optimize the thickness and material of the dielectric coating, always as a function of the dynamic response of the droplets. Then, to avoid contamination issues, a number of analogue fluids are proposed, in a new approach, which are characterized and tested in the second part of the work. Regarding the characterization of these new fluids, preliminary results suggest a great potential of a surfactant solution to be used as an analogue. The addition of the surfactant results in the formation of semi-rigid particles with a size distribution and deformation characteristics compatible with those of the biosamples to be studied. The surfactant solution also shows a swift response to electrostatic actuation.

Download


Paper Citation


in Harvard Style

Moita A., Caldeira C., Jacinto F., Lima R., Vega E. and Moreira A. (2019). Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device.In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, ISBN 978-989-758-353-7, pages 99-107. DOI: 10.5220/0007578100990107


in Bibtex Style

@conference{biodevices19,
author={A. Moita and C. Caldeira and F. Jacinto and R. Lima and E. Vega and A. Moreira},
title={Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,},
year={2019},
pages={99-107},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007578100990107},
isbn={978-989-758-353-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,
TI - Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device
SN - 978-989-758-353-7
AU - Moita A.
AU - Caldeira C.
AU - Jacinto F.
AU - Lima R.
AU - Vega E.
AU - Moreira A.
PY - 2019
SP - 99
EP - 107
DO - 10.5220/0007578100990107