Design and Development of Parallel Biosensing System for Personalized Chemotherapy Treatment

Ahmad Fairuzabadi Mohd Mansor, Anis Nordin, Kian Liang Goh, Soon Hin How, Yumi Zuhanis Has-Yun Hashim, Mardhiah Mohammad

Abstract

Cancer treatment, especially chemotherapy can cause very painful side effects such as nausea, fatigue, diarrhoea and nerve damage. Efficient treatment of cancer is when the most appropriate drug and dosage is given to patients' such that it increases their disease-free survival rates but minimizes pain. Currently, oncologists subject cancer patients to a standard chemotherapeutic regimen based on the type and grade of tumour. However, tumour behaviours are unpredictable and are often different for each individual patient. Personalized studies predicting a patient's response to chemotherapeutic treatment are rarely done since it involves tedious end-point measurements and drug preparation. Usage of personalized biosensors, where cultured cancer cells from each patient are tested with different chemotherapy agents can change this. This allows clinicians to predict the best chemotherapy agent or combination of agents that are likely to be successful against the patient’s tumours without subjecting patients to ineffective therapy, increasing clinical response and minimizing adverse effects. In this research, a biosensing system based on Electrical Cell-Substrate Impedance Sensing (ECIS) concept will be designed and developed to monitor adhesion, proliferation and death of cancer cells in vitro due to exposure to chemotherapy drugs. Chemosensitivity analysis will be performed using the developed impedance biosensing system by correlating the response of cell samples towards several chemotherapy regimens. A comparison will be made between tests conducted using biosensors and the actual chemotherapy treatment prescribed to patients.

Download


Paper Citation


in Harvard Style

Mohd Mansor A., Nordin A., Goh K., How S., Hashim Y. and Mohammad M. (2019). Design and Development of Parallel Biosensing System for Personalized Chemotherapy Treatment.In Doctoral Consortium - Volume 1: DCBIOSTEC, ISBN , pages 15-19


in Bibtex Style

@conference{dcbiostec19,
author={Ahmad Fairuzabadi Mohd Mansor and Anis Nordin and Kian Liang Goh and Soon Hin How and Yumi Zuhanis Has-Yun Hashim and Mardhiah Mohammad},
title={Design and Development of Parallel Biosensing System for Personalized Chemotherapy Treatment},
booktitle={Doctoral Consortium - Volume 1: DCBIOSTEC,},
year={2019},
pages={15-19},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={},
}


in EndNote Style

TY - CONF

JO - Doctoral Consortium - Volume 1: DCBIOSTEC,
TI - Design and Development of Parallel Biosensing System for Personalized Chemotherapy Treatment
SN -
AU - Mohd Mansor A.
AU - Nordin A.
AU - Goh K.
AU - How S.
AU - Hashim Y.
AU - Mohammad M.
PY - 2019
SP - 15
EP - 19
DO -