Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens

Adelya Irawan Manalu, It Jamilah, Sovia Lenny

2019

Abstract

Quorum-sensing is a specific communication type among microbial species, exposing several virulence factors to host or internal environment. The phenomenon is currently being studied as potential target for drug discovery and development. Natural product derived from plant source may be evaluated as potential quorum-sensing inhibitor (QSI). The study aimed to determine the optimum concentration of Andaliman methanolic (MeOH) and ethyl acetate extract (EtOAc) against prodigiosin synthesis by Serratia marcescens as one of phenotypes controlled by quorum sensing. Based on optical density (OD600), both extracts did not interfere with the growth of microorganism. The optimum concentration of MeOH extract in inhibiting the prodigiosin synthesis was at concentration of 0.05% (w/v) in the end of incubation period (30 h). Meanwhile, the EtOAc extract inhibit the prodigiosin synthesis at concentration of 0.4% in the end of incubation period. Our results showed that Andaliman possess natural products as QSI which needed further evaluation in the future.

Paper Citation

in Harvard Style

Manalu A., Jamilah I. and Lenny S. (2019). Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens.In Proceedings of the International Conference on Natural Resources and Technology - Volume 1: ICONART, ISBN 978-989-758-404-6, pages 87-90. DOI: 10.5220/0008506300870090

in Bibtex Style

@conference{iconart19,
author={Adelya Irawan Manalu and It Jamilah and Sovia Lenny},
title={Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens},
booktitle={Proceedings of the International Conference on Natural Resources and Technology - Volume 1: ICONART,},
year={2019},
pages={87-90},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008506300870090},
isbn={978-989-758-404-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Natural Resources and Technology - Volume 1: ICONART,
TI - Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens
SN - 978-989-758-404-6
AU - Manalu A.
AU - Jamilah I.
AU - Lenny S.
PY - 2019
SP - 87
EP - 90
DO - 10.5220/0008506300870090