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Authors: Hanif Sri Utami ; Benny Nelson ; Eyleny Meisyah Fitri ; Windy Keumala Budianti and Endi Novianto

Affiliation: Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Indonesia

Keyword(s): pityriasis rubra pilaris, retinol, therapy, vitamin A

Abstract: Pityriasis rubra pilaris (PRP) is a rare and chronic papulosquamous disorder of unknown etiology that often progresses to erythroderma and causes a disabling palmoplantar keratoderma. Genetic factors with an autosomal dominant pattern of inheritance have been supposed to play a critical role for the induction of PRP. Vitamin A deficiency was also believed to be related to the disorder. Treatment of PRP is mainly anecdotal, based on case reports and case series, a feature shared by many disorders in dermatology due to their rarity. Currently, oral retinoids and methotrexate are the first line of therapy in patients with PRP. Response to therapy varies in each patient.We report a 46-year-old male patient with erythroderma and hyperkeratotic palms and soles since two years ago. Histopathological findings were consistent with PRP. The patients had been treated with several systemic therapies, yet showed poor clinical response. Clinical improvement was seen after 16 weeksaddition of oral vitamin A at a dosage of 200.000 IU daily in concurrent with 10 mg weekly methotrexate. Evaluation of potential adverse effects was closely monitored.Oral vitamin A, an old regimen,seems to be a favorable adjuvant treatment for refractory PRP. (More)

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Paper citation in several formats:
Utami, H.; Nelson, B.; Fitri, E.; Budianti, W. and Novianto, E. (2020). Oral Vitamin A as an Adjuvant Treatment for Refractory Pityriasis Rubra Pilaris (PRP). In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - ICTROMI; ISBN 978-989-758-469-5, SciTePress, pages 295-298. DOI: 10.5220/0009987102950298

@conference{ictromi20,
author={Hanif Sri Utami. and Benny Nelson. and Eyleny Meisyah Fitri. and Windy Keumala Budianti. and Endi Novianto.},
title={Oral Vitamin A as an Adjuvant Treatment for Refractory Pityriasis Rubra Pilaris (PRP)},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - ICTROMI},
year={2020},
pages={295-298},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009987102950298},
isbn={978-989-758-469-5},
}

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - ICTROMI
TI - Oral Vitamin A as an Adjuvant Treatment for Refractory Pityriasis Rubra Pilaris (PRP)
SN - 978-989-758-469-5
AU - Utami, H.
AU - Nelson, B.
AU - Fitri, E.
AU - Budianti, W.
AU - Novianto, E.
PY - 2020
SP - 295
EP - 298
DO - 10.5220/0009987102950298
PB - SciTePress

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