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Authors: Flavio Esposito 1 ; Lucia Sansone 2 ; Anubhav Srivastava 1 ; Angela Maria Cusano 3 ; Stefania Campopiano 1 ; Michele Giordano 2 and Agostino Iadiccico 1

Affiliations: 1 Department of Engineering, University of Naples “Parthenope”, 80143 Napoli, Italy ; 2 Institute for Polymers, Composites and Biomaterials, National Research Council of Italy (CNR), 80055 Portici, Italy ; 3 Regional Centre on Information Communication Technology (CeRICT) scrl, 82100 Benevento, Italy

Keyword(s): Long Period Gratings, Fiber Optic Sensor, Graphene Oxide, Biosensor, Vitamin D.

Abstract: The label-free detection of vitamin D by employing fiber optic biosensor is reported in this work. Here, the long period grating (LPG) which is inscribed into a specialty fiber i.e., double cladding fiber (DCF) having W-type refractive index profile, is basically employed as a foundation for biosensing. The wet-chemical etching is performed to the outer cladding of the fiber to induce mode transition phenomenon which resulted in an enhanced sensitivity of -1400 nm/RIU towards surrounding medium along with significant visibility (> 15 dB) of grating’s resonance band. The sensing surface of an LPG device is then coated with a graphene oxide (GO) layer of nanometric thickness providing carboxylic functional groups for grafting of 25-OH-D3 specific antibody for vitamin D3. Finally, the detection of vitamin D3 was tested using concentrations in buffer solutions within the clinical range of 1-100 ng/mL resulting a limit of detection (LOD) lower than 1 ng/mL.

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Paper citation in several formats:
Esposito, F.; Sansone, L.; Srivastava, A.; Cusano, A.; Campopiano, S.; Giordano, M. and Iadiccico, A. (2022). Long Period Grating based Biosensing Technology for the Detection of Vitamin D3 . In Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - AOMatDev; ISBN 978-989-758-554-8; ISSN 2184-4364, SciTePress, pages 191-198. DOI: 10.5220/0010973000003121

@conference{aomatdev22,
author={Flavio Esposito. and Lucia Sansone. and Anubhav Srivastava. and Angela Maria Cusano. and Stefania Campopiano. and Michele Giordano. and Agostino Iadiccico.},
title={Long Period Grating based Biosensing Technology for the Detection of Vitamin D3 },
booktitle={Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - AOMatDev},
year={2022},
pages={191-198},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010973000003121},
isbn={978-989-758-554-8},
issn={2184-4364},
}

TY - CONF

JO - Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - AOMatDev
TI - Long Period Grating based Biosensing Technology for the Detection of Vitamin D3
SN - 978-989-758-554-8
IS - 2184-4364
AU - Esposito, F.
AU - Sansone, L.
AU - Srivastava, A.
AU - Cusano, A.
AU - Campopiano, S.
AU - Giordano, M.
AU - Iadiccico, A.
PY - 2022
SP - 191
EP - 198
DO - 10.5220/0010973000003121
PB - SciTePress

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