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Authors: Erola Pairo 1 ; Santiago Marco 1 and Alexandre Perera 2

Affiliations: 1 Universitat de Barcelona, Spain ; 2 CIBER de Bioingeniera, Materiales y Nanomedicina (CIBER-BBN), Spain

Keyword(s): Transcription factors, Binding sites, Principal components analysis.

Related Ontology Subjects/Areas/Topics: Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Biomedical Signal Processing ; Data Manipulation ; Health Engineering and Technology Applications ; Human-Computer Interaction ; Methodologies and Methods ; Neurocomputing ; Neurotechnology, Electronics and Informatics ; Pattern Recognition ; Physiological Computing Systems ; Sensor Networks ; Soft Computing

Abstract: Transcription starts when multiple proteins, known as transcription factors recognize and bind to transcription start site in DNA sequences. Since mutation in transcription factor binding sites are known to underlie diseases it remains a major challenge to identify these binding sites. Conversion from symbolic DNA to numerical sequences and genome data make it possible to construct a detector based on a numerical analysis of DNA binding sites. A subspace model for the TFBS is built. TFBS will show a very small distance to this particular subspace. Using this distance binding sites are distinguished from random sequences and from genome data.

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Paper citation in several formats:
Pairo, E.; Marco, S. and Perera, A. (2009). A PRELIMINARY STUDY ON THE DETECTION OF TRANSCRIPTION FACTOR BINDING SITES. In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2009) - BIOSIGNALS; ISBN 978-989-8111-65-4; ISSN 2184-4305, SciTePress, pages 506-509. DOI: 10.5220/0001550305060509

@conference{biosignals09,
author={Erola Pairo. and Santiago Marco. and Alexandre Perera.},
title={A PRELIMINARY STUDY ON THE DETECTION OF TRANSCRIPTION FACTOR BINDING SITES},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2009) - BIOSIGNALS},
year={2009},
pages={506-509},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001550305060509},
isbn={978-989-8111-65-4},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2009) - BIOSIGNALS
TI - A PRELIMINARY STUDY ON THE DETECTION OF TRANSCRIPTION FACTOR BINDING SITES
SN - 978-989-8111-65-4
IS - 2184-4305
AU - Pairo, E.
AU - Marco, S.
AU - Perera, A.
PY - 2009
SP - 506
EP - 509
DO - 10.5220/0001550305060509
PB - SciTePress

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