Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis

Cyril Gobinet; Ali Tfayli; Olivier Piot; Valeriu Vrabie; Régis Huez

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Paper

Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis

In Proceedings of the 1st International Workshop on Biosignal Processing and Classification - Volume 0ICINCO, 19-26, 2005 , Barcelona, Spain

Authors: Cyril Gobinet ¹ ; Ali Tfayli ² ; Olivier Piot ² ; Valeriu Vrabie ¹ and Régis Huez ¹

Affiliations: ¹ CReSTIC, URCA, France ; ² Unité MéDIAN, CNRS UMR 6142, URCA, France

Abstract: This paper deals with a promising methodology for melanoma early diagnosis. Raman spectroscopy is used to record vibrational information of paraffinised tumoral tissues. Independent Component Analysis (ICA) is performed on Raman spectra to numerically deparaffinise spectra. Resulting deparaffinised spectra are used to extract discriminant information specific to malignant and benign tumors. These spectral specificities can be employed as molecular descriptors of the type of pathology. A comparison with Principal Component Analysis (PCA) shows that ICA is more suited to process this kind of problem.

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Paper citation in several formats:

Gobinet, C.; Tfayli, A.; Piot, O.; Vrabie, V. and Huez, R. (2005). Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis. In Proceedings of the 1st International Workshop on Biosignal Processing and Classification (ICINCO 2005) - BPC; ISBN 972-8865-35-X, SciTePress, pages 19-26. DOI: 10.5220/0001195500190026

@conference{bpc05,
author={Cyril Gobinet. and Ali Tfayli. and Olivier Piot. and Valeriu Vrabie. and Régis Huez.},
title={Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis},
booktitle={Proceedings of the 1st International Workshop on Biosignal Processing and Classification (ICINCO 2005) - BPC},
year={2005},
pages={19-26},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001195500190026},
isbn={972-8865-35-X},
}

TY - CONF

JO - Proceedings of the 1st International Workshop on Biosignal Processing and Classification (ICINCO 2005) - BPC
TI - Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis
SN - 972-8865-35-X
AU - Gobinet, C.
AU - Tfayli, A.
AU - Piot, O.
AU - Vrabie, V.
AU - Huez, R.
PY - 2005
SP - 19
EP - 26
DO - 10.5220/0001195500190026
PB - SciTePress