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Authors: Adéla Šterberová 1 ; Andreea Dincu 1 ; Stijn Oudshoorn 1 ; Vincent van Duinen 2 and Lu Cao 1

Affiliations: 1 Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands ; 2 Leiden University Medical Center, Leiden, The Netherlands

Keyword(s): Tumor Angiogenesis, Petri Nets, Endothelial Cell Transition, VEGF Gradient.

Abstract: Tumor angiogenesis concerns the development of new blood vessels supplying the necessary nutrients for the further development of existing tumor cells. The entire process is complex, involving the production and consumption of chemicals, endothelial cell transitions as well as cell interactions, divisions, and migrations. Microfluidic cell culture platform has been used to study angiogenesis of endothelial cells derived from human induced pluripotent stem cells (iPSC-ECs) for a physiological relevant micro-environment. In this paper, we elaborate on how to define a pipeline for simulating the transformation and process that an iPSC-derived endothelial cell goes through in this biological scenario. We leverage the robustness and simplicity of Petri nets for modeling the cell transformation and associated constraints. The environmental and spacial factors are added using custom 2-dimensional grids. Although the pipeline does not capture the entire complexity of tumor angiogenesis, we a re able to capture the essence of endothelial cell transitions in tumor angiogenesis using this conceptually simplified solution. (More)

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Paper citation in several formats:
Šterberová, A.; Dincu, A.; Oudshoorn, S.; van Duinen, V. and Cao, L. (2024). Modeling iPSC-Derived Endothelial Cell Transition in Tumor Angiogenesis Using Petri Nets. In Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS; ISBN 978-989-758-688-0; ISSN 2184-4305, SciTePress, pages 337-346. DOI: 10.5220/0012268800003657

@conference{bioinformatics24,
author={Adéla Šterberová. and Andreea Dincu. and Stijn Oudshoorn. and Vincent {van Duinen}. and Lu Cao.},
title={Modeling iPSC-Derived Endothelial Cell Transition in Tumor Angiogenesis Using Petri Nets},
booktitle={Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS},
year={2024},
pages={337-346},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012268800003657},
isbn={978-989-758-688-0},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS
TI - Modeling iPSC-Derived Endothelial Cell Transition in Tumor Angiogenesis Using Petri Nets
SN - 978-989-758-688-0
IS - 2184-4305
AU - Šterberová, A.
AU - Dincu, A.
AU - Oudshoorn, S.
AU - van Duinen, V.
AU - Cao, L.
PY - 2024
SP - 337
EP - 346
DO - 10.5220/0012268800003657
PB - SciTePress

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