Authors:
Sarah Mahri
;
Teffy Nuary
;
Fadhli A. Mughni
and
Windy Keumala B.
Affiliation:
Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia / Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Keyword(s):
Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Treatments
Abstract:
Stevens-Johnson syndrome (SJS) and/or toxic epidermal necrolysis (TEN) are drug reactions associated to
high morbidity and mortality. Prompt diagnosis and management may reduce the mortality rate. The
research aims to evaluate the consistency of current treatments for SJS/TEN with the clinical pathway by
Dr. Cipto Mangunkusumo National General Hospital and Indonesian Society of Dermatology And
Venereology (ISDV). A retrospective review was conducted on patients with SJS/TEN admitted to Dr.
Cipto Mangunkusumo National General Hospital, Jakarta during January 2014 to December 2017. The data
were collected from paper-based and electronic health medical record database. A total of 34 cases of
SJS/TEN were admitted, but only 30 cases with complete data was included, comprising of 20 males and 10
females with the mean age were 37.5 (15-70) years. Carbamazepin was the most common culprit drug. All
patients were treated with intravenous methylprednisolone. The average length of stay were 6 d
ays (3-20) in
SJS, 8 (3-18) in SJS-TEN, and 11 (4-18) in TEN, while the mortality rate were 18.2% in SJS, 8.3% in SJS-
TEN, and 14.3% in TEN. As conclusion, corticosteroids may contribute to reduced mortality rate in
SJS/TEN without increasing secondary infection and serious sequele. The current treatments for SJS/TEN
in our hospital is consistent with the clinical pathway by Dr. Cipto Mangunkusumo National General
Hospital and Indonesian Society of Dermatology And Venereology (ISDV). Further well-designed studies
are required to compare the effect of corticosteroids treatment for SJS/TEN to other medications.
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