Authors:
Marcos Javier Teperino
1
;
María Paula Bonomini
1
;
Pablo Daniel Cruces
2
and
Pedro David Arini
2
Affiliations:
1
Universidad de Buenos Aires, Argentina
;
2
Universidad de Buenos Aires and Instituto Argentino de Matemática, Argentina
Keyword(s):
Ventricular Repolarization Dispersion, T-wave Morphology, Age.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Signal Processing
;
Cardiovascular Signals
Abstract:
Abnormal modifications in ventricular repolarization dispersion (VRD) have been shown to constitute a substrate for malignant arrhythmias. In this work, we have induced abrupt heart rate (HR) changes to young and middle-aged healthy subjects through a Tilt-test and have analyzed the evolution of several VRD indices. Duration ones, based on electrocardiogram intervals; energy ones, developed through a Principal Components Analysis (PCA) in T-wave; and the morphology ones, extracted feature from an absolute T-wave. In both groups, results have shown significant decreases in early repolarization duration. These changes are responsible for the alterations in the total repolarization duration, because T-wave peak-to-end has not shown statistical significance. Moreover, we have found significant decreases in total, early and late repolarization energy, and in the T-wave amplitude. In another sense, we have observed that the repolarization energy obtained by PCA jointly with early T-wave sl
ope and amplitude have been able to reflect VRD differences between young and middle-aged subjects. Finally, this work provides the range of values for VRD in normal conditions during abrupt HR changes. Outside this range, we could assume that it exists a cardiac risk.
(More)