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Authors: D. S. Ferreira 1 ; M. Henriques 1 ; R. Oliveira 1 ; J. H. Correia 1 and G. Minas 2

Affiliations: 1 Universidade do Minho, Portugal ; 2 University of Minho, Portugal

Keyword(s): Autofluorescence, Fluorophores, Cancer, Optical sensors.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instruments and Devices ; Devices ; Health Monitoring Devices ; Human-Computer Interaction ; Physiological Computing Systems

Abstract: Human tissues show autofluorescence (AF) emission spectra when excited by ultraviolet or short-wavelength visible light. The intensity and shape of these spectra are dependent on the tissues pathological state and, therefore, its measurement gives information about the degree of malignant transformations that could lead to cancer. In this article, it is characterized the AF spectra of one human gastrointestinal carcinoma cell line (CACO-2). The obtained results showed significant AF signal for the presence of amino acids. The spectral information obtained can be used for the design of fluorescence optical sensors that will be incorporated on an endoscopic capsule, for measuring the AF emission spectra of normal and cancer cells. This integrated optical system will innovate on the diagnosis of early stage cancer.

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Paper citation in several formats:
Ferreira, D.; Henriques, M.; Oliveira, R.; Correia, J. and Minas, G. (2009). AUTOFLUORESCENCE SPECTROSCOPY OF A HUMAN GASTROINTESTINAL CARCINOMA CELL LINE - Design of Optical Sensors for the Detection of Early Stage Cancer. In Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES; ISBN 978-989-8111- 64-7; ISSN 2184-4305, SciTePress, pages 61-66. DOI: 10.5220/0001539000610066

@conference{biodevices09,
author={D. S. Ferreira. and M. Henriques. and R. Oliveira. and J. H. Correia. and G. Minas.},
title={AUTOFLUORESCENCE SPECTROSCOPY OF A HUMAN GASTROINTESTINAL CARCINOMA CELL LINE - Design of Optical Sensors for the Detection of Early Stage Cancer},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES},
year={2009},
pages={61-66},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001539000610066},
isbn={978-989-8111- 64-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES
TI - AUTOFLUORESCENCE SPECTROSCOPY OF A HUMAN GASTROINTESTINAL CARCINOMA CELL LINE - Design of Optical Sensors for the Detection of Early Stage Cancer
SN - 978-989-8111- 64-7
IS - 2184-4305
AU - Ferreira, D.
AU - Henriques, M.
AU - Oliveira, R.
AU - Correia, J.
AU - Minas, G.
PY - 2009
SP - 61
EP - 66
DO - 10.5220/0001539000610066
PB - SciTePress

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