Authors:
Maik Hadorn
1
and
Peter Eggenberger Hotz
2
Affiliations:
1
University of Zurich, Switzerland
;
2
University of Southern Denmark, Denmark
Keyword(s):
Personalized healthcare, Drug delivery, Encapsulation, Compartmentalization, Vesicle, Liposome.
Related
Ontology
Subjects/Areas/Topics:
Biomaterials
;
Biomedical Engineering
;
Biomedical Instruments and Devices
;
Emerging Technologies
;
Nanotechnologies
;
Telecommunications
;
Wireless and Mobile Technologies
;
Wireless Information Networks and Systems
Abstract:
Single liposomes and vesicles are successfully utilized as delivery vehicles of pharmaceuticals. However limitations of these unilamellar, single compartments led to the development of encapsulated multicompartment systems that establishes the prospect of multicomponent or multifunctional drug delivery systems. So far compartmentalization is restricted to binary systems. To realize a personalized drug delivery, a programmable linkage of n-entities of different content will be needed. Here we present both a programmable DNA-mediated linkage of three distinct vesicle populations and a novel encapsulation protocol. We discuss how the techniques established in this study might be used in personalized healthcare based on custom-tailored encapsulated multicompartment vesicular drug delivery systems.