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Authors: Adelya Irawan Manalu 1 ; It Jamilah 1 and Sovia Lenny 2

Affiliations: 1 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia, Indonesia ; 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia

Keyword(s): Andaliman, Quorum-sensing inhibitor, Serratia marcescens, Zanthoxylum acanthopodium DC.

Abstract: Quorum-sensing is a specific communication type among microbial species, exposing several virulence factors to host or internal environment. The phenomenon is currently being studied as potential target for drug discovery and development. Natural product derived from plant source may be evaluated as potential quorum-sensing inhibitor (QSI). The study aimed to determine the optimum concentration of Andaliman methanolic (MeOH) and ethyl acetate extract (EtOAc) against prodigiosin synthesis by Serratia marcescens as one of phenotypes controlled by quorum sensing. Based on optical density (OD600), both extracts did not interfere with the growth of microorganism. The optimum concentration of MeOH extract in inhibiting the prodigiosin synthesis was at concentration of 0.05% (w/v) in the end of incubation period (30 h). Meanwhile, the EtOAc extract inhibit the prodigiosin synthesis at concentration of 0.4% in the end of incubation period. Our results showed that Andaliman possess natural p roducts as QSI which needed further evaluation in the future. (More)

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Paper citation in several formats:
Manalu, A.; Jamilah, I. and Lenny, S. (2019). Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens. In Proceedings of the International Conference on Natural Resources and Technology - ICONART; ISBN 978-989-758-404-6, SciTePress, pages 87-90. DOI: 10.5220/0008506300870090

@conference{iconart19,
author={Adelya Irawan Manalu. and It Jamilah. and Sovia Lenny.},
title={Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens},
booktitle={Proceedings of the International Conference on Natural Resources and Technology - ICONART},
year={2019},
pages={87-90},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008506300870090},
isbn={978-989-758-404-6},
}

TY - CONF

JO - Proceedings of the International Conference on Natural Resources and Technology - ICONART
TI - Potency of Andaliman (Zanthoxylum acanthopodium DC.) Extracts as Quorum-sensing Inhibitor to Serratia marcescens
SN - 978-989-758-404-6
AU - Manalu, A.
AU - Jamilah, I.
AU - Lenny, S.
PY - 2019
SP - 87
EP - 90
DO - 10.5220/0008506300870090
PB - SciTePress

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