Authors:
            
                    Alessandro Savino
                    
                        
                                1
                            
                    
                    ; 
                
                    Alfredo Benso
                    
                        
                                1
                            
                    
                    ; 
                
                    Stefano Di Carlo
                    
                        
                                2
                            
                    
                    ; 
                
                    Valentina Giannini
                    
                        
                                3
                            
                    
                    ; 
                
                    Anna Vignati
                    
                        
                                3
                            
                    
                    ; 
                
                    Gianfranco Politano
                    
                        
                                3
                            
                    
                    ; 
                
                    Simone Mazzetti
                    
                        
                                2
                            
                    
                     and
                
                    Daniele Regge
                    
                        
                                4
                            
                    
                    
                
        
        
            Affiliations:
            
                    
                        
                                1
                            
                    
                    Department of Control and Computer Engineering and Consorzio Interuniversitario Nazionale per l’Informatica, Italy
                
                    ; 
                
                    
                        
                                2
                            
                    
                    Department of Control and Computer Engineering, Italy
                
                    ; 
                
                    
                        
                                3
                            
                    
                    Institute for Cancer Research and Treatment, Italy
                
                    ; 
                
                    
                        
                                4
                            
                    
                    Institute for Cancer Research and Treatment and Candiolo (TO), Italy
                
        
        
        
        
        
             Keyword(s):
            Prostate Cancer, Computer Aided Diagnosis, Malignancies Probabilistic Classification, Magnetic Resonance
Imaging (MRI), Software Design.
        
        
            
                Related
                    Ontology
                    Subjects/Areas/Topics:
                
                        Bioimaging
                    ; 
                        Biomedical Engineering
                    ; 
                        Cardiovascular Imaging and Cardiography
                    ; 
                        Cardiovascular Technologies
                    ; 
                        Health Engineering and Technology Applications
                    ; 
                        Image Archiving and Communication
                    ; 
                        Magnetic Resonance Imaging
                    ; 
                        Medical Imaging and Diagnosis
                    ; 
                        NeuroSensing and Diagnosis
                    ; 
                        Neurotechnology, Electronics and Informatics
                    ; 
                        Quantitative Bioimaging
                    
            
        
        
            
                Abstract: 
                Prostate Cancer (PCa) is the most common solid neoplasm in males and a major cause of cancer-related death.
Screening based on Prostate Specific Antigen (PSA) reduces the rate of death by 31%, but it is associated
with a high risk of over-diagnosis and over-treatment. Prostate Magnetic Resonance Imaging (MRI) has the
potential to improve the specificity of PSA-based screening scenarios as a non-invasive detection tool. Research
community effort focused on classification techniques based on MRI in order to produce a malignancy
likelihood map. The paper describes the prototyping design, the implemented work-flow and the software
architecture of a Computer Aided Diagnosis (CAD) software which aims at providing a comprehensive diagnostic
tool, including an integrated classification stack, from a preliminary registration of images to the
classification process. This software can improve the diagnostic accuracy of the radiologist, reduce reader
variability and speed up the whole diagnostic
                 work-up.
                (More)