Authors:
Alessandro Savino
1
;
Alfredo Benso
1
;
Stefano Di Carlo
2
;
Valentina Giannini
3
;
Anna Vignati
3
;
Gianfranco Politano
3
;
Simone Mazzetti
2
and
Daniele Regge
4
Affiliations:
1
Department of Control and Computer Engineering and Consorzio Interuniversitario Nazionale per l’Informatica, Italy
;
2
Department of Control and Computer Engineering, Italy
;
3
Institute for Cancer Research and Treatment, Italy
;
4
Institute for Cancer Research and Treatment and Candiolo (TO), Italy
Keyword(s):
Prostate Cancer, Computer Aided Diagnosis, Malignancies Probabilistic Classification, Magnetic Resonance
Imaging (MRI), Software Design.
Related
Ontology
Subjects/Areas/Topics:
Bioimaging
;
Biomedical Engineering
;
Cardiovascular Imaging and Cardiography
;
Cardiovascular Technologies
;
Health Engineering and Technology Applications
;
Image Archiving and Communication
;
Magnetic Resonance Imaging
;
Medical Imaging and Diagnosis
;
NeuroSensing and Diagnosis
;
Neurotechnology, Electronics and Informatics
;
Quantitative Bioimaging
Abstract:
Prostate Cancer (PCa) is the most common solid neoplasm in males and a major cause of cancer-related death.
Screening based on Prostate Specific Antigen (PSA) reduces the rate of death by 31%, but it is associated
with a high risk of over-diagnosis and over-treatment. Prostate Magnetic Resonance Imaging (MRI) has the
potential to improve the specificity of PSA-based screening scenarios as a non-invasive detection tool. Research
community effort focused on classification techniques based on MRI in order to produce a malignancy
likelihood map. The paper describes the prototyping design, the implemented work-flow and the software
architecture of a Computer Aided Diagnosis (CAD) software which aims at providing a comprehensive diagnostic
tool, including an integrated classification stack, from a preliminary registration of images to the
classification process. This software can improve the diagnostic accuracy of the radiologist, reduce reader
variability and speed up the whole diagnostic
work-up.
(More)