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Authors: Frieti Vega Nela 1 ; Heny Arwati 2 and Yoes Prijatna Dachlan 2

Affiliations: 1 Department of Immunology Postgraduate School Airlangga University,Surabaya, East Java and Indonesia, Indonesia ; 2 Department of Parasitology, Faculty of Medicine, Airlangga University,Surabaya, East Java and Indonesia, Indonesia

Keyword(s): Parasite Density, TNF-α, IL-10, Plasmodium vivax

Abstract: Introduction. Annual parasite incidence (API) in East Nusa Tenggara Province (NTT) 2015 per 1000 population is 7.04%. However, API in each Public Health Center (Puskesmas) Sumba Island remains high. High levels of pro-inflammatory cytokines in malaria infection, such as TNF-α is associated with severe pathology, whereas, anti-inflammatory cytokines such as IL-10 is associated with acute malaria. The objective of the study was to analyze correlation between parasite densities and plasma level of both cytokines in P. vivax-infected patients in East Sumba Regency East Nusa Tenggara Province. Methods. Parasite densities were calculated per 500 leucocytes on Giemsa-stained thick blood smears. The levels of TNF-α and IL-10 were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical analyses were done by Spearman test. Results. Correlation was observed significantly in parasite density and TNF-α p = 0.032 and parasite density and IL-10 p=0.000. This result indicated that the stage of immunity in patients was not affected by the parasite density but clinical symptoms may have a greater role in increasing and decreasing the plasma level of cytokines. Conclusion. There was correlation between parasite densities and plasma level of TNF-α and IL-10 in P. vivax infected patients is the studied areas. (More)

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Paper citation in several formats:
Nela, F.; Arwati, H. and Dachlan, Y. (2019). Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province. In Proceedings of the 2nd International Conference Postgraduate School - ICPS; ISBN 978-989-758-348-3, SciTePress, pages 325-328. DOI: 10.5220/0007542203250328

@conference{icps19,
author={Frieti Vega Nela. and Heny Arwati. and Yoes Prijatna Dachlan.},
title={Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - ICPS},
year={2019},
pages={325-328},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007542203250328},
isbn={978-989-758-348-3},
}

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - ICPS
TI - Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province
SN - 978-989-758-348-3
AU - Nela, F.
AU - Arwati, H.
AU - Dachlan, Y.
PY - 2019
SP - 325
EP - 328
DO - 10.5220/0007542203250328
PB - SciTePress

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