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Authors: Peter Kupfer 1 ; Sebastian Vlaic 1 ; René Huber 2 ; Raimund W. Kinne 3 and Reinhard Guthke 1

Affiliations: 1 Hans-Knöll-Institute, Germany ; 2 Hannover Medical School, Germany ; 3 Friedrich Schiller University, Germany

Keyword(s): Network Inference, Rheumatoid Arthritis, TNF-a, TGF-b1, IL-1, PDGF-D.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology ; Transcriptomics

Abstract: Since genetic and epigenetic factors are known to be involved in the pathogenesis of rheumatoid arthritis the search for key players in this disease is one of the most important challenges. For this purpose gene regulatory networks are one possibility to reveal underlying interactions for different stimuli. In this study we analyzed the cellular response of synovial fibroblasts to 4 different stimuli. We infered a gene regulatory network that is able to explain the observed data for stimulation by TNF-a, TGF-b1, IL-1 and PDGF-D simultaneously.

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Paper citation in several formats:
Kupfer, P.; Vlaic, S.; Huber, R.; W. Kinne, R. and Guthke, R. (2013). Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS; ISBN 978-989-8565-35-8; ISSN 2184-4305, SciTePress, pages 282-287. DOI: 10.5220/0004196402820287

@conference{bioinformatics13,
author={Peter Kupfer. and Sebastian Vlaic. and René Huber. and Raimund {W. Kinne}. and Reinhard Guthke.},
title={Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS},
year={2013},
pages={282-287},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004196402820287},
isbn={978-989-8565-35-8},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS
TI - Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis
SN - 978-989-8565-35-8
IS - 2184-4305
AU - Kupfer, P.
AU - Vlaic, S.
AU - Huber, R.
AU - W. Kinne, R.
AU - Guthke, R.
PY - 2013
SP - 282
EP - 287
DO - 10.5220/0004196402820287
PB - SciTePress

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