Authors:
Karine Charrière
1
;
Alain Rouleau
2
;
Olivier Gaiffe
2
;
Pascal Morel
3
;
Véronique Bourcier
1
;
Christian Pieralli
2
;
Wilfrid Boireau
2
;
Lionel Pazart
1
and
Bruno Wacogne
4
Affiliations:
1
Besançon University Hospital, France
;
2
UMR CNRS 6174, France
;
3
Etablissement Français du Sang Bourgogne/Franche-Comté, France
;
4
Besançon University Hospital and UMR CNRS 6174, France
Keyword(s):
Biosensor, Surface Plasmon Resonance, Human Red Blood Cells, Automated ABO Compatibility Test, Optical Detection, Opto-Fluidic Prototype.
Related
Ontology
Subjects/Areas/Topics:
Biocomputing and Biochips
;
Biomedical Engineering
;
Biomedical Instrumentation
;
Biomedical Instruments and Devices
;
Biomedical Sensors
Abstract:
In blood transfusion, accidents still occur because of ABO mismatch between donor and patient’s blood.
These errors, sometimes lethal, are principally due to wrong identification of patient and/or blood product or
to human errors. The best way to avoid these errors is to perform an ultimate ABO compatibility test at the
patient’s bedside immediately prior to transfusion. Ideally, this test should be performed automatically,
without human interpretation and with minimum blood exposure for nurses. This ideal and ultimate method
is not yet employed because of the lack of suitable device. In this paper, we propose a system that may fulfil
the above mentioned requirements. It is based on selective blood capture on biochip surfaces in a device
which automatically drives the different fluids, performs optical detection of captured red cells and finally
interprets the optical reading in terms of ABO compatibility. So far, our device achieved blood
compatibility test with 99.3 % sensitivity a
nd 97.9 % specificity.
(More)