Authors:
V. G. Almeida
1
;
J. Borba
1
;
H. C. Pereira
2
;
T. Pereira
1
;
J. Cardoso
1
and
C. Correia
1
Affiliations:
1
University of Coimbra, Portugal
;
2
University of Coimbra and ISA- Intelligent Sensing Anywhere, Portugal
Keyword(s):
Arterial Distension Waveform, Augmentation Index, Clinical Validation, Repeatability Trials, Angiography Intervention.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Signal Processing
;
Cardiovascular Signals
Abstract:
The arterial distension waveform (ADW) analysis is a reliable technique for cardiovascular function assessment.
The purpose of this study was to perform the pre-clinical validation of a non-invasive prototype focusing
the repeatability tests and cross-relationships between different subject groups. The evaluation focused parameters
retrieved from ADW: systolic peak (SP), dicrotic notch (DN), RP (reflection point) and Augmentation
index (AI). One hundred and fifty one subjects (61 men and 90 women, aged between 18 and 80 years) were
assigned into four groups based on their clinical characteristics. Database is constituted by healthy, hypertensive
and subjects that suffer from stenosis. The cross-correlations analysis between groups allows establishing
time parameterizations for each one. Furthermore, the differences between the left and right carotid artery
suggest intrinsically variability for each one of the subjects. The coefficient of variation (CV) mean value
obtained for all mea
surements was 18.58%, maximum rate of 33.7% and minimum 8.9%. The stenosis case
study demonstrate the potentialities of the use of this prototype in the detection of cardiac anomalies by the
monitoring of state alterations through RP, SP and DN time parameterizations with visible changes in RP and
SP values (after carotid intervention RP appears later than SP, in opposition with values before intervention),
while DN associated time changes little. The tests performed on the ADW showed that is possible the reliable
measurement of morphological patterns changes.
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