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Authors: C. Ramos 1 ; P. Napoleão 2 ; C. Fondinho 3 ; M. Selas 3 ; M. Mota Carmo 4 ; R. Cruz Ferreira 4 and T. Pinheiro 1

Affiliations: 1 Universidade Técnica de Lisboa, Portugal ; 2 Instituto de Medicina Molecular, Portugal ; 3 Hospital de Santa Marta CHLC, Portugal ; 4 Hospital de Santa Marta CHLC, Faculdade de Ciências Médicas and Universidade Nova de Lisboa, Portugal

Keyword(s): VH-IVUS, Biomarkers, Expansive Plaque, Plaque Vulnerability.

Abstract: The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.

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Paper citation in several formats:
Ramos, C.; Napoleão, P.; Fondinho, C.; Selas, M.; Mota Carmo, M.; Cruz Ferreira, R. and Pinheiro, T. (2013). Expansive Growth of Atherosclerotic Plaques Assessed by VH-IVUS - Association with TNF-α and OX-LDL Levels in Circulation. In Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio; ISBN 978-989-8565-78-5, SciTePress, pages 90-94. DOI: 10.5220/0004664500900094

@conference{visualcardio13,
author={C. Ramos. and P. Napoleão. and C. Fondinho. and M. Selas. and M. {Mota Carmo}. and R. {Cruz Ferreira}. and T. Pinheiro.},
title={Expansive Growth of Atherosclerotic Plaques Assessed by VH-IVUS - Association with TNF-α and OX-LDL Levels in Circulation},
booktitle={Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio},
year={2013},
pages={90-94},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004664500900094},
isbn={978-989-8565-78-5},
}

TY - CONF

JO - Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio
TI - Expansive Growth of Atherosclerotic Plaques Assessed by VH-IVUS - Association with TNF-α and OX-LDL Levels in Circulation
SN - 978-989-8565-78-5
AU - Ramos, C.
AU - Napoleão, P.
AU - Fondinho, C.
AU - Selas, M.
AU - Mota Carmo, M.
AU - Cruz Ferreira, R.
AU - Pinheiro, T.
PY - 2013
SP - 90
EP - 94
DO - 10.5220/0004664500900094
PB - SciTePress

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