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Authors: Mónica G. Larese and Juan C. Gómez

Affiliation: Lab. for System Dynamics and Signal Processing, FCEIA, UNR, Argentina

ISBN: 978-989-8111-60-9

Keyword(s): Bioinformatics, cDNA microarrays, image analysis, automatic addressing.

Related Ontology Subjects/Areas/Topics: Image and Video Processing, Compression and Segmentation ; Multimedia ; Multimedia Signal Processing ; Telecommunications

Abstract: In this paper a novel procedure based on texture spatial characterization techniques is proposed aimed at automatically addressing spots in microarray images. The algorithm relies on the regular and pseudo-periodic patterns of spots, which can be considered as texture primitives. A fully automatic procedure is proposed to segment the autocorrelation functions of subgrid images and accurately determine the locations of the peaks. These candidate peaks, i.e., vectors, are next used to compute the displacement vectors that fully characterize the spatial arrangement of spots, describing the spot spacing and angle of rotation of the pattern. A refinement procedure is then applied to improve the accuracy of the norms and angles of the displacement vectors. An ideal template is generated using the computed spanning vectors, which is deformed and adjusted via Markov Random Fields (MRF) modelling. Experiments based on artificial and real images are promising, showing improvements regarding ro bustness against image rotations, and accuracy, over results provided by state-of-the-art methods. (More)

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Paper citation in several formats:
G. Larese M.; C. Gómez J. and (2008). ACCURATE AUTOMATIC SPOT ADDRESSING FOR MICROARRAY IMAGES.In Proceedings of the International Conference on Signal Processing and Multimedia Applications - Volume 1: SIGMAP, (ICETE 2008) ISBN 978-989-8111-60-9, pages 221-224. DOI: 10.5220/0001941202210224

@conference{sigmap08,
author={Mónica {G. Larese} and Juan {C. Gómez}},
title={ACCURATE AUTOMATIC SPOT ADDRESSING FOR MICROARRAY IMAGES},
booktitle={Proceedings of the International Conference on Signal Processing and Multimedia Applications - Volume 1: SIGMAP, (ICETE 2008)},
year={2008},
pages={221-224},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001941202210224},
isbn={978-989-8111-60-9},
}

TY - CONF

JO - Proceedings of the International Conference on Signal Processing and Multimedia Applications - Volume 1: SIGMAP, (ICETE 2008)
TI - ACCURATE AUTOMATIC SPOT ADDRESSING FOR MICROARRAY IMAGES
SN - 978-989-8111-60-9
AU - G. Larese, M.
AU - C. Gómez, J.
PY - 2008
SP - 221
EP - 224
DO - 10.5220/0001941202210224

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