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Authors: Yasser Alzamil 1 ; 2 ; Yulia Hicks 1 ; Xin Yang 1 and Christopher Marshall 3

Affiliations: 1 Cardiff University, School of Engineering, United Kingdom ; 2 University of Hail, Applied Medical Sciences College, Saudi Arabia ; 3 Cardiff University, United Kingdom

Keyword(s): PET, Patlak Graphical Analysis, 18F-FDOPA Quantification, Image Analysis, Dpetstep Simulation.

Abstract: Graphical analysis techniques are often applied to positron emission tomography (PET) images to estimate physiological parameters. Patlak analysis is primarily used to obtain the rate constant (Ki) that indicates the transfer of a tracer from plasma to the irreversible compartment and ultimately describes how the tracer binds to the targeted tissue. One of the most common issues associated with Patlak analysis is the introduction of statistical noise that affects the slope of the graphical plot and causes bias. In this study, several statistical methods are proposed and applied to PET time activity curves (TACs) for both reversible and irreversible regions that are involved in the equation. A dynamic PET imaging simulator for the Patlak model was used to evaluate the statistical methods employed to reduce the bias introduced in the acquired data.

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Paper citation in several formats:
Alzamil, Y.; Hicks, Y.; Yang, X. and Marshall, C. (2018). Optimising Graphical Techniques Applied to Irreversible Tracers . In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIOIMAGING; ISBN 978-989-758-278-3; ISSN 2184-4305, SciTePress, pages 17-26. DOI: 10.5220/0006513700170026

@conference{bioimaging18,
author={Yasser Alzamil. and Yulia Hicks. and Xin Yang. and Christopher Marshall.},
title={Optimising Graphical Techniques Applied to Irreversible Tracers },
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIOIMAGING},
year={2018},
pages={17-26},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006513700170026},
isbn={978-989-758-278-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIOIMAGING
TI - Optimising Graphical Techniques Applied to Irreversible Tracers
SN - 978-989-758-278-3
IS - 2184-4305
AU - Alzamil, Y.
AU - Hicks, Y.
AU - Yang, X.
AU - Marshall, C.
PY - 2018
SP - 17
EP - 26
DO - 10.5220/0006513700170026
PB - SciTePress

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