Authors:
Yu Yong Choi
1
and
Kun Ho Lee
2
Affiliations:
1
Hanyang University, Korea, Republic of
;
2
Chosun University, Korea, Republic of
Keyword(s):
heritability, structural equation modeling, Falconer’s formula, neuroimaging, correction of multiple comparisons.
Abstract:
Heritability is the proportion of total phenotypic variance due to genetic influence. To estimate heritability, Falconer’s method and structural equation modeling (SEM) are used. However, compared to Falconer’s formula, SEM is hardly applicable for neuroimaging analysis because the SEM tools such as Mx cannot calculate numerous data simultaneously nor sequentially. We developed a code for multiple calculations using Mx to estimate the heritability of gray matter thickness at 81,924 surface points across the cerebral cortex. Although FF and SEM provided similar results, SEM was inclined to yield lower heritability estimates and more conservative significance than Falconer’s method. In considering the results, we propose that the correction for multiple comparisons should be carefully performed for the results from SEM.