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Authors: Njagi Mwaniki 1 ; Erik Garrison 2 and Nadia Pisanti 1

Affiliations: 1 University of Pisa, Italy ; 2 University of Tennessee Health Science Center, U.S.A.

Keyword(s): D-string, Pangenome, Pattern Matching.

Abstract: A D-strings is a degenerate string representing similar and aligned strings by collapsing common fragments and highlighting variants. D-strings can represent a MSA or a pan-genome. In this paper we propose a new, fast and exact method to align a string to a D-string. In recent years, aligning a sequence to a pangenome has become a central problem in computational genomics and pangenomics. A fast and accurate solution to this problem can serve as a toolkit to many crucial tasks such as read-correction, Multiple Sequences Alignment (MSA), genome assemblies, and variant calling, just to name a few. An implementation of our tool is publicly available on github at https://github.com/urbanslug/dsa.

CC BY-NC-ND 4.0

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Paper citation in several formats:
Mwaniki, N.; Garrison, E. and Pisanti, N. (2023). Fast Exact String to D-Texts Alignments. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - BIOINFORMATICS; ISBN 978-989-758-631-6; ISSN 2184-4305, SciTePress, pages 70-79. DOI: 10.5220/0011666900003414

@conference{bioinformatics23,
author={Njagi Mwaniki. and Erik Garrison. and Nadia Pisanti.},
title={Fast Exact String to D-Texts Alignments},
booktitle={Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - BIOINFORMATICS},
year={2023},
pages={70-79},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011666900003414},
isbn={978-989-758-631-6},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - BIOINFORMATICS
TI - Fast Exact String to D-Texts Alignments
SN - 978-989-758-631-6
IS - 2184-4305
AU - Mwaniki, N.
AU - Garrison, E.
AU - Pisanti, N.
PY - 2023
SP - 70
EP - 79
DO - 10.5220/0011666900003414
PB - SciTePress