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Authors: Tjerignimin Silue ; Saugandhika Minnikanti and Nathalia Peixoto

Affiliation: George Mason University, United States

Keyword(s): Vitreous Humor, Stainless Steel Electrodes, Electrochemistry, Characterization, Cyclic Voltammetry, Electrochemical Impedance Spectroscopy, Randles Model.

Abstract: The vitreous is a gel-like structure found in the eyes. It is located above the retina to prevent the passage of fluids. As aging occurs, the vitreous can liquefy and can cause retinal detachment. The literature has little characterization of the vitreous, as it is often a less interesting structure than the retinal tissue. We investigate the impedance properties of the stimulation electrodes such as the constant phase element (Q) and the resistance of the solution (Rsol). We show results on vitreous characterization through electrochemical methods as a first step toward understanding the role of electrical stimulation in retinal prosthetics applications as it pertains to vitreous liquefaction. Our objective is to characterize the vitreous for a wide frequency range and to determine how charge is distributed through its conductive structure. Our electrochemical experiments were performed using insulated stainless steel electrodes (1) in phosphate buffered saline (PBS) and (2) in thim erosal as controls, (3) in vitreous without thimerosal, as well as (4) in vitreous preserved with thimerosal. We also performed cyclic voltammetry to measure the cathodic charge storage capacity for the electrodes for all experimental groups. Our results showed that the resistivity of the vitreous increases as thimerosal is added and that the cathodic charge storage capacity of the vitreous does not show any significant difference in the means as thimerosal is added. (More)

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Paper citation in several formats:
Silue, T.; Minnikanti, S. and Peixoto, N. (2017). Randles Model of Vitreous Humor. In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2017) - BIODEVICES; ISBN 978-989-758-216-5; ISSN 2184-4305, SciTePress, pages 156-162. DOI: 10.5220/0006166001560162

@conference{biodevices17,
author={Tjerignimin Silue. and Saugandhika Minnikanti. and Nathalia Peixoto.},
title={Randles Model of Vitreous Humor},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2017) - BIODEVICES},
year={2017},
pages={156-162},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006166001560162},
isbn={978-989-758-216-5},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2017) - BIODEVICES
TI - Randles Model of Vitreous Humor
SN - 978-989-758-216-5
IS - 2184-4305
AU - Silue, T.
AU - Minnikanti, S.
AU - Peixoto, N.
PY - 2017
SP - 156
EP - 162
DO - 10.5220/0006166001560162
PB - SciTePress

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