Theoretical Study of the Fidelity of Transcription

Yao-Gen Shu; Yao-Gen Shu; Ming Li; Zhong-Can Ou-Yang

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Paper

Theoretical Study of the Fidelity of Transcription

Topics: Transcriptomics

In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOSTEC, 239-241, 2020 , Valletta, Malta

Authors: Yao-Gen Shu ^{1

;

2} ; Ming Li ³ and Zhong-Can Ou-Yang ²

Affiliations: ¹ Bioinformatics Laboratory of Yishang Innovation Technology Co., Ltd, Beijing 100081, China ; ² Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China ; ³ School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Keyword(s): Gene Transcription Fidelity, First-passage Approach, First-order Neighbor Effects.

Abstract: This year we celebrate the 50th anniversary of the discovery of the three eukaryotic RNA polymerases. Ever since this seminal event was uncovered by Robert Roeder in 1969(Roeder and Rutter, 1969), researchers have investigated the intricate mechanisms of gene transcription with great dedication. However, there is not breakthrough in study of the fidelity of transcription still. Here, we propose a simplest model with first-order neighbor effects, a first-passage approach, to theoretically investigate the gene transcription fidelity.

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Paper citation in several formats:

Shu, Y.; Li, M. and Ou-Yang, Z. (2020). Theoretical Study of the Fidelity of Transcription. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS; ISBN 978-989-758-398-8; ISSN 2184-4305, SciTePress, pages 239-241. DOI: 10.5220/0009181002390241

@conference{bioinformatics20,
author={Yao{-}Gen Shu. and Ming Li. and Zhong{-}Can Ou{-}Yang.},
title={Theoretical Study of the Fidelity of Transcription},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS},
year={2020},
pages={239-241},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009181002390241},
isbn={978-989-758-398-8},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS
TI - Theoretical Study of the Fidelity of Transcription
SN - 978-989-758-398-8
IS - 2184-4305
AU - Shu, Y.
AU - Li, M.
AU - Ou-Yang, Z.
PY - 2020
SP - 239
EP - 241
DO - 10.5220/0009181002390241
PB - SciTePress