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Authors: András Hartmann 1 ; Susana Vinga 2 and Joao M. Lemos 3

Affiliations: 1 INESC-ID, Portugal ; 2 INESC-ID and FCM-UNL, Portugal ; 3 INESC-ID and IST-UTL, Portugal

Keyword(s): Systems biology, Lactococcus lactis, Modeling, Glucose uptake.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Model Design and Evaluation ; Systems Biology

Abstract: Dynamic modeling of the metabolism is one of the main research areas of systems biology. A typical but yet unresolved problem is the modeling of glucose uptake of Lactococcus lactis bacteria upon in-vivo NMR measurements in perturbation experiments. Most modelers are focusing on the inverse problem, namely to identify the parameters of a set of differential equations using the available dataset. Majority of the available models suffer from the drawback that even if a perfect fit to a single experiment was achieved, they can not explain the systems’ behavior in different experimental conditions. The aim of this study is to introduce an appropriate method and a model to fit one set of parameters to several different experiments, enabling unify modeling of the glucose decay of the bacteria. With the proposed approach a good overall fit was obtained to the dataset. The results confirm that this could be a future way towards unified modeling of data with heterogeneous experimental condit ions. (More)

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Paper citation in several formats:
Hartmann, A.; Vinga, S. and M. Lemos, J. (2011). UNIFIED MODELING OF SEVERAL PERTURBATION EXPERIMENTS IN SYSTEMS BIOLOGY - A Case Study on the Glucose Uptake of Lactococcus Lactis. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS; ISBN 978-989-8425-36-2; ISSN 2184-4305, SciTePress, pages 309-312. DOI: 10.5220/0003158103090312

@conference{bioinformatics11,
author={András Hartmann. and Susana Vinga. and Joao {M. Lemos}.},
title={UNIFIED MODELING OF SEVERAL PERTURBATION EXPERIMENTS IN SYSTEMS BIOLOGY - A Case Study on the Glucose Uptake of Lactococcus Lactis},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS},
year={2011},
pages={309-312},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003158103090312},
isbn={978-989-8425-36-2},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS
TI - UNIFIED MODELING OF SEVERAL PERTURBATION EXPERIMENTS IN SYSTEMS BIOLOGY - A Case Study on the Glucose Uptake of Lactococcus Lactis
SN - 978-989-8425-36-2
IS - 2184-4305
AU - Hartmann, A.
AU - Vinga, S.
AU - M. Lemos, J.
PY - 2011
SP - 309
EP - 312
DO - 10.5220/0003158103090312
PB - SciTePress

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