Authors:
Melonie Burrows
1
;
Graeme Jahns
1
;
Geoffrey Houlton
1
;
Berry van Gelder
2
and
Frank Marcus
3
Affiliations:
1
Heart Force Medical Inc., Canada
;
2
Catharina Hospital, Netherlands
;
3
The University Medical Centre, United States
Keyword(s):
Cardiac Resynchronization Therapy, Seismocardiography, Ballistocardiography, Biventricular pacing, Heart failure.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Instruments and Devices
;
Biomedical Sensors
;
Devices
;
Electrocardiography and Heart Monitoring
;
Emerging Technologies
;
Health Monitoring Devices
;
Human-Computer Interaction
;
Physiological Computing Systems
;
Telecommunications
;
Wireless and Mobile Technologies
;
Wireless Information Networks and Systems
Abstract:
Cardiac resynchronization therapy (CRT) results in improved clinical status in patients with heart failure and left ventricular dyssynchrony. One third of CRT patients fail to respond due to the inability to 1) identify non-responders prior to treatment, 2) optimize coronary sinus lead placement for left ventricular pacing and 3) optimize the atrio-ventricular (A-V) and inter-ventricular (V-V) intervals. Although invasive measurements of first maximal derivative of left ventricular pressure (dP/dtmax) are used to optimize lead placement and A-V and V-V intervals in CRT, it would be preferable to have a non-invasive assessment of dP/dtmax. Echocardiographic dyssynchrony and left ventricular function are current parameters for non-invasively evaluating responders to CRT, but they are not recommended due to their poor reproducibility. We applied recent advances in technology to develop a device called the digital ballistocardiograph (dBG®), which assesses the mechanical function of the
heart using triaxial accelerometry. We show that dBG® cardiac events are valid in comparison to 2D transthoracic echocardiography and reliable in comparison to cardiac magnetic resonance imaging. We present preliminary data to support our position that the dBG® could be used as a non-invasive assessment of dP/dtmax in heart failure patients to identify responders and optimize CRT.
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