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Authors: Karine Charrière 1 ; Jean-Francois Manceau 2 ; Pascal Morel 3 ; Véronique Bourcier 1 ; Wilfrid Boireau 2 ; Lionel Pazart 1 and Bruno Wacogne 2 ; 1

Affiliations: 1 Besançon University Hospital, France ; 2 FEMTO-ST Institute, Univ. Bourgogne Franche-Comté, France ; 3 Etablissement Français du Sang Bourgogne/Franche-Comté, France

Keyword(s): Red Cells Incompatibility, Blood Transfusion, Microsystem, Medical Device, Transfusion Safety, Acoustic Mixing, Acoustic Detection.

Abstract: During red cells concentrates transfusion, red cells incompatibilities still occur despite the laboratory controls based on immuno-hematologic techniques. Red cells incompatibilities appear when patient’s antibodies bind to red cells to be transfused. Up to now, all pre-transfusion testing are addressed using techniques based on immunology. This is time consuming, expensive and some incompatibility situations cannot be addressed at the patient’s bedside. In this position paper, we propose a completely novel paradigm. Our hypothesis is that red blood cells sensitized by the patient’s antibodies see their deformability greatly reduced. This induces changes of the rheological properties of the “red cells concentrate /patient’s blood” mixture. Studies described in this position paper aim at characterizing these modifications by measuring the characteristics of acoustic waves propagating in the mixture and to produce a mobile and automated acousto-micro-fluidic device which would allow de tecting any incompatibility at the patient’s bed side. (More)

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Paper citation in several formats:
Charrière, K.; Manceau, J.; Morel, P.; Bourcier, V.; Boireau, W.; Pazart, L. and Wacogne, B. (2018). Test Device for Blood Transfusion Safety. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIODEVICES; ISBN 978-989-758-277-6; ISSN 2184-4305, SciTePress, pages 206-211. DOI: 10.5220/0006635702060211

@conference{biodevices18,
author={Karine Charrière. and Jean{-}Francois Manceau. and Pascal Morel. and Véronique Bourcier. and Wilfrid Boireau. and Lionel Pazart. and Bruno Wacogne.},
title={Test Device for Blood Transfusion Safety},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIODEVICES},
year={2018},
pages={206-211},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006635702060211},
isbn={978-989-758-277-6},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - BIODEVICES
TI - Test Device for Blood Transfusion Safety
SN - 978-989-758-277-6
IS - 2184-4305
AU - Charrière, K.
AU - Manceau, J.
AU - Morel, P.
AU - Bourcier, V.
AU - Boireau, W.
AU - Pazart, L.
AU - Wacogne, B.
PY - 2018
SP - 206
EP - 211
DO - 10.5220/0006635702060211
PB - SciTePress

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