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Authors: Ramona Hodrea 1 ; Sandra Iulianetti 2 ; Clara Ionescu 1 and Robin De Keyser 1

Affiliations: 1 Ghent University, Belgium ; 2 Faculté Polytechnique de Mons, Belgium

Keyword(s): Modeling, Anesthesia, Drug delivery.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Signal Processing ; Physiological Processes and Bio-Signal Modeling, Non-Linear Dynamics

Abstract: This paper presents the development of a MISO (multiple-input single-output) patient model for sedation and analgesia components used in ICU. The two inputs are Propofol and Remifentanil and the output is the Bispectral Index. The MISO model consists of two well-known PK-PD models for Propofol and Remifentanil, and an interaction model which describes the synergistic effect of these two drugs on the Bispectral Index. The interaction model parameters were identified using a nonlinear least squares method. Data collected during clinical trials in ICU at Ghent University Hospital have been used for model development. The final purpose is to use this model for prediction in a model based predictive control strategy.

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Paper citation in several formats:
Hodrea, R.; Iulianetti, S.; Ionescu, C. and De Keyser, R. (2010). MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2010) - BIOSIGNALS; ISBN 978-989-674-018-4; ISSN 2184-4305, SciTePress, pages 145-150. DOI: 10.5220/0002591101450150

@conference{biosignals10,
author={Ramona Hodrea. and Sandra Iulianetti. and Clara Ionescu. and Robin {De Keyser}.},
title={MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA },
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2010) - BIOSIGNALS},
year={2010},
pages={145-150},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002591101450150},
isbn={978-989-674-018-4},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2010) - BIOSIGNALS
TI - MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA
SN - 978-989-674-018-4
IS - 2184-4305
AU - Hodrea, R.
AU - Iulianetti, S.
AU - Ionescu, C.
AU - De Keyser, R.
PY - 2010
SP - 145
EP - 150
DO - 10.5220/0002591101450150
PB - SciTePress

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