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Authors: Eti Meirina Brahmana 1 ; Jamaran Kaban 2 ; Ginda Haro 3 ; Juliati Br Tarigan 4 ; Basuki Wirjosentono 5 ;  Tamrin 4 and Mimpin Ginting 4

Affiliations: 1 Postgraduate Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1 Kampus USU, Medan, Biology Study Program, Faculty of Teaching Training and Education, Universitas Pasir Pengaraian, Indonesia ; 2 Department of Chemistry, Universitas Sumatera Utara, Jl. Bioteknologi No. 1 Kampus USU, Medan, North Sumatera, Indonesia (ID), Indonesia ; 3 Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma Kampus USU, Medan, North Sumatera, Indonesia, Indonesia ; 4 Department of Chemistry, Universitas Sumatera Utara, Jl. Bioteknologi No. 1 Kampus USU, Medan, North Sumatera, Indonesia, Indonesia ; 5 Department of Chemistry, Universitas Sumatera Utara, Jl. Bioteknologi No. 1 Kampus USU, Medan, North Sumatera,, Indonesia

Keyword(s): Antioxidant, Chalcone, Synthesis, Toxicity.

Abstract: Halogen substituted analog compound chalcone (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 3- bromoacetophenone, as ketones by using aldol condensation reaction. The compound resulted rendement with value of 62,38% and characterized by using UV, IR, MS, and 1HNMR. Test of antioxidant activity using DPPH method showed that those compounds have low potency as antioxidant agent LC50 with value 571, 7903 ppm. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value 7,94 μg/mL.

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Paper citation in several formats:
Brahmana, E.; Kaban, J.; Haro, G.; Br Tarigan, J.; Wirjosentono, B.; Tamrin. and Ginting, M. (2020). Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on. In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - ICOCSTI; ISBN 978-989-758-415-2, SciTePress, pages 5-9. DOI: 10.5220/0008836400050009

@conference{icocsti20,
author={Eti Meirina Brahmana. and Jamaran Kaban. and Ginda Haro. and Juliati {Br Tarigan}. and Basuki Wirjosentono. and Tamrin. and Mimpin Ginting.},
title={Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - ICOCSTI},
year={2020},
pages={5-9},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008836400050009},
isbn={978-989-758-415-2},
}

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - ICOCSTI
TI - Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on
SN - 978-989-758-415-2
AU - Brahmana, E.
AU - Kaban, J.
AU - Haro, G.
AU - Br Tarigan, J.
AU - Wirjosentono, B.
AU - Tamrin.
AU - Ginting, M.
PY - 2020
SP - 5
EP - 9
DO - 10.5220/0008836400050009
PB - SciTePress

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