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Authors: Ali Ayadi 1 ; Cecilia Zanni-Merk 2 and François de Beuvron de Bertrand 2

Affiliations: 1 ICUBE/SDC Team (UMR CNRS 7357), Institut Supérieur de Gestion de Tunis and University of Tunis, France ; 2 ICUBE/SDC Team (UMR CNRS 7357), France

Keyword(s): Biomolecular Networks, Dynamical Modelling, Qualitative Reasoning, Qualitative Simulation.

Related Ontology Subjects/Areas/Topics: Applications and Case-studies ; Artificial Intelligence ; Biomedical Engineering ; Expert Systems ; Health Information Systems ; Knowledge Engineering and Ontology Development ; Knowledge Representation ; Knowledge-Based Systems ; Symbolic Systems

Abstract: Understanding the dynamical behaviour of cellular systems requires the development of effective modelling techniques. The modeling aims to facilitate the study and understanding of the dynamic behaviour of these systems, by the simulation of their designed models. Complex biomolecular networks are the basis of these models. In this paper, we propose a method of qualitative reasoning, based on a formal logical modeling, to qualitatively simulate the biomolecular network and interpret it behaviour over time. The power of our approach is illustrated by applying it to the case study of the autoregulation of the bacteriophage T4 gene 32.

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Paper citation in several formats:
Ayadi, A.; Zanni-Merk, C. and de Beuvron de Bertrand, F. (2016). Qualitative Reasoning for Understanding the Behaviour of Complex Biomolecular Networks. In Proceedings of the 8th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management (IC3K 2016) - KEOD; ISBN 978-989-758-203-5; ISSN 2184-3228, SciTePress, pages 144-149. DOI: 10.5220/0006065901440149

@conference{keod16,
author={Ali Ayadi. and Cecilia Zanni{-}Merk. and Fran\c{C}ois {de Beuvron de Bertrand}.},
title={Qualitative Reasoning for Understanding the Behaviour of Complex Biomolecular Networks},
booktitle={Proceedings of the 8th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management (IC3K 2016) - KEOD},
year={2016},
pages={144-149},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006065901440149},
isbn={978-989-758-203-5},
issn={2184-3228},
}

TY - CONF

JO - Proceedings of the 8th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management (IC3K 2016) - KEOD
TI - Qualitative Reasoning for Understanding the Behaviour of Complex Biomolecular Networks
SN - 978-989-758-203-5
IS - 2184-3228
AU - Ayadi, A.
AU - Zanni-Merk, C.
AU - de Beuvron de Bertrand, F.
PY - 2016
SP - 144
EP - 149
DO - 10.5220/0006065901440149
PB - SciTePress

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