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Author: Jesus Miro-Bueno

Affiliation: Research Institute of the IT4Innovations Centre of Excellence, Faculty of Philosophy and Science and Silesian University in Opava, Czech Republic

Keyword(s): Multicellular Clock, Synchronization, Genetic Clock, Positive Feedback, Synthetic Gene Oscillator.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology

Abstract: Genetic oscillators are present in a wide range of organisms from bacteria to neurons and coordinate important biological functions. Current models of genetic oscillators are based on auto-repressed genes. In these models a gene produces a repressor protein that binds to the promoter of its own gene repressing the transcription. Different versions of these models have been studied in living organisms and for engineering synthetic clocks. Synchronization of genetic clocks based on this model has also been studied. However, genes with positive feedbacks are also present in natural and synthetic genetic clocks. These self-activating genes provide robustness and frequency tuning to genetic clocks. In this paper we show a novel role of self-activating genes. We demonstrate that the coupling of self-activating genes by small molecules in a cell population produces synchronized oscillations. Our model could be useful for engineering new robust multicellular clocks and better understanding o f natural genetic oscillators. (More)

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Paper citation in several formats:
Miro-Bueno, J. (2015). Coupling of Self-activating Genes Induces Spontaneous Synchronized Oscillations in Cells. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS; ISBN 978-989-758-070-3; ISSN 2184-4305, SciTePress, pages 121-127. DOI: 10.5220/0005216801210127

@conference{bioinformatics15,
author={Jesus Miro{-}Bueno.},
title={Coupling of Self-activating Genes Induces Spontaneous Synchronized Oscillations in Cells},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS},
year={2015},
pages={121-127},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005216801210127},
isbn={978-989-758-070-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS
TI - Coupling of Self-activating Genes Induces Spontaneous Synchronized Oscillations in Cells
SN - 978-989-758-070-3
IS - 2184-4305
AU - Miro-Bueno, J.
PY - 2015
SP - 121
EP - 127
DO - 10.5220/0005216801210127
PB - SciTePress

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