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Authors: Maria Soares 1 ; Jorge Correia 1 ; José Cabeçadas 2 ; Conceição Peleteiro 3 and Fernando Ferreira 1

Affiliations: 1 Technical University of Lisbon, Portugal ; 2 Anatomical Pathology Service and IPOFG-EPE, Portugal ; 3 Faculty of Veterinary Medicine, Portugal

Keyword(s): Feline mammary carcinoma, fHER-2, diagnosis

Abstract: The overexpression of the Human Epidermal growth factor Receptor-2 (HER-2) oncogene in human breast cancer is associated with a poor prognosis and a specific treatment. Because of its importance and as a first line option for diagnosis, well established guidelines for its detection are based in immunohistochemical techniques, Still, in Veterinary Medicine there is little and inconsistent information about this subject. The aim of our study was to achieve an optimal immunohistochemical protocol for detection of fHER-2 in Feline Mammary Carcinoma (FMC). Five commercial anti-HER-2 antibodies were tested using three different protocols. The fHER-2 protein overexpression was detected in 10 of the 30 FMC cases (33.3%), when the optimized protocol was performed (associating the A0485 antibody with a longer antigen retrieval method). These results suggest that fHER-2 may play an important role in Feline Oncology and that the Cat can be a suitable animal model for human breast cancer research.

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Paper citation in several formats:
Soares, M.; Correia, J.; Cabeçadas, J.; Peleteiro, C. and Ferreira, F. (2012). The Value of a New Cancer Biomarker fHER-2 Proto-oncogene in the Diagnosis of Feline Mammary Carcinoma. In Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB; ISBN 978-989-8425-94-2, SciTePress, pages 9-17. DOI: 10.5220/0003879300090017

@conference{vbb12,
author={Maria Soares. and Jorge Correia. and José Cabe\c{C}adas. and Concei\c{C}ão Peleteiro. and Fernando Ferreira.},
title={The Value of a New Cancer Biomarker fHER-2 Proto-oncogene in the Diagnosis of Feline Mammary Carcinoma},
booktitle={Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB},
year={2012},
pages={9-17},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003879300090017},
isbn={978-989-8425-94-2},
}

TY - CONF

JO - Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB
TI - The Value of a New Cancer Biomarker fHER-2 Proto-oncogene in the Diagnosis of Feline Mammary Carcinoma
SN - 978-989-8425-94-2
AU - Soares, M.
AU - Correia, J.
AU - Cabeçadas, J.
AU - Peleteiro, C.
AU - Ferreira, F.
PY - 2012
SP - 9
EP - 17
DO - 10.5220/0003879300090017
PB - SciTePress

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